Survival of developing dopaminergic neurons in reaggregate tissue culture following treatment with methamphetamine.
Survival of developing dopaminergic neurons in reaggregate tissue culture following treatment with methamphetamine.
复制标题
用甲基苯丙胺治疗后重新聚集组织培养物中发育中的多巴胺能神经元的存活率。
DOI：
10.1016/0304-3940(91)90474-8
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
Heller,A
中科院分区：
文献类型：
--
作者：
Kontur,PJ;Won,LA;Hoffmann,PC;Heller,A
Developing central dopamine (DA)-containing neurons in rotation-mediated reaggregate tissue culture exposed to 10−4M methamphetamine for 1 week (at a time corresponding to the 2nd week of postnatal development) exhibit decreased DA levels. DA neurons were visualized either by a histofluorescent method after ‘loading’ with exogenous DA, or by tyrosine hydroxylase (TH) immunocytochemistry. An apparent loss of histofluorescent DA cell bodies was observed due to a methamphetamine-induced reduction in exogenous DA accumulation. No decrease in the number of TH-immunoreactive neurons was observed. Thus, developing DA neurons when visualized by TH immunocytochemistry survive despite methamphetamine-induced reductions in DA levels.
