Powder bed dynamics of a single-tablet-scale vibratory mixing process
Powder bed dynamics of a single-tablet-scale vibratory mixing process
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单片规模振动混合过程的粉床动力学
DOI：
10.1016/j.powtec.2022.118029
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发表时间：
2022
影响因子：
5.2
通讯作者：
J. Khinast
中科院分区：
文献类型：
--
作者：
Andreas Kottlan;B. Glasser;J. Khinast
振动混合是混合药物粉末以生产固体剂型的一种有前景的技术。在这项研究中，我们评估了单片规模振动混合装置内的颗粒动力学，以深入了解扩散和对流混合对混合性能的贡献。为了研究振动参数的影响，振动频率在 100 到 300 Hz 之间变化，并保持相似的加速度振幅。粒子动力学评估是通过高速视频记录和 PIV 分析来实现的。实验表明，振动频率较低时，搅拌开始速度更快，平均速度幅度更高，颗粒表观温度更高。主要负责快速混合的稀释区的尺寸随着频率的增加而减小。与文献中混合性能研究的比较表明，观察到的分散系数与混合速度之间存在良好的相关性，表明扩散混合机制是这种单片规模混合过程的主要驱动因素。
Vibratory mixing is a promising technique for the blending of pharmaceutical powders to produce solid dosage forms. In this study we evaluate the particle dynamics inside a single-tablet-scale vibratory mixing device, to gain insight on the contributions of diffusive and convective mixing on the blending performance. To investigate the influence of vibration parameters, the frequency of vibration is varied from 100 to 300 Hz keeping similar acceleration amplitudes. Particle-dynamics evaluation is realized using high-speed video recordings and PIV-analysis. The experiments showed faster onset of agitation, higher average velocity magnitudes, and higher apparent granular temperatures for lower vibration frequencies. The size of the dilute zones, predominately responsible for rapid mixing, decreased with increasing frequency. Comparison with studies on the mixing performance from literature revealed a good correlation between the observed dispersion coefficient and the mixing speed, indicating that diffusive mixing mechanisms are the major driving factor in this single-tablet-scale blending process.
影响因子：
16.6
作者：
Garcia-Moreno, Francisco;Kamm, Paul Hans;Banhart, John
通讯作者：
Banhart, John