Polydimethyl siloxane wet etching for three dimensional fabrication of microneedle array and high-aspect-ratio micropillars
Polydimethyl siloxane wet etching for three dimensional fabrication of microneedle array and high-aspect-ratio micropillars
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DOI：
10.1063/1.4871038
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发表时间：
2014-03-01
期刊：
影响因子：
3.2
通讯作者：
Juang, Yi-Je
中科院分区：
文献类型：
--
作者：
Deng, Yu-Luen;Juang, Yi-Je
在各种经皮药物递送（TDD）方法中，利用微针（MN）不仅可以穿透皮肤，而且可以在减少组织损伤、减少疼痛和无出血的情况下递送药物。然而，需要具有较大高度的MN来克服皮肤屏障以实现有效的TDD。与2D图案化不同，提出了用于制造3D微结构的蚀刻聚二甲基硅氧烷（PDMS）微柱。首先通过将PDMS浇铸在计算机数控加工的圆柱形微孔上来构建PDMS微柱，然后通过蚀刻工艺来获得MN，以用于后续的聚合物MN或高纵横比微柱的制造。(C)2014 AIP Publishing LLC.
Among various transdermal drug delivery (TDD) approaches, utilizing the microneedles (MNs) not only can penetrate the skin but also deliver the drug with reduced tissue damage, reduced pain, and no bleeding. However, the MNs with larger height are required to overcome the skin barrier for effective TDD. Unlike 2D patterning, etching polydimethyl siloxane (PDMS) micropillars for fabrication of 3D microstructures is presented. The PDMS micropillars were first constructed by casting PDMS on the computer numerical control-machined cylindrical microwells, which then went through etching process to obtain the MNs for subsequent fabrication of polymer MNs or high aspect ratio micropillars. (C) 2014 AIP Publishing LLC.