Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport.
Effect of linoleic and oleic acids on blood pressure, blood viscosity, and erythrocyte cation transport.
复制标题
亚油酸和油酸对血压、血液粘度和红细胞阳离子转运的影响。
DOI：
10.1080/07315724.1987.10720179
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发表时间：
1987
影响因子：
3.5
通讯作者：
Kass,EH
中科院分区：
文献类型：
--
作者：
Sacks,FM;Stampfer,MJ;Munoz,A;McManus,K;Canessa,M;Kass,EH
已经提出，膳食亚油酸通过转化为花生四烯酸和二烯系列的前列腺素来降低血压（BP）。我们测试了亚油酸对血浆花生四烯酸、血压、血液粘度和红细胞阳离子转运的影响。油酸是主要的膳食单不饱和脂肪，不是前列腺素前体，用作对照。17名成年人每天摄入23 g由红花种子遗传变异体提供的亚油酸或油酸，每个人在双盲交叉设计中持续4周。亚油酸和油酸丰富的血浆胆固醇酯，磷脂和甘油三酯在各自的补充期间，但没有增加花生四烯酸。摄入油酸期间的平均BP为116.1/76.8，摄入亚油酸期间的平均BP为113.6/74.6（收缩压p = 0.09，舒张压p = 0.12）。该研究的功效超过75%，可检测到4 mm Hg对收缩压或舒张压的显著影响（p <0.05）。在方案期间，全血和血浆粘度、RBC Li/Na反向转运、Na/K共转运和Na泵系统（Vmax）未发生变化。因此，饮食中亚油酸或油酸的变化不太可能对血压或与高血压相关的几种膜依赖性红细胞功能产生重大影响。
It has been proposed that dietary linoleic acid lowers blood pressure (BP) by being converted to arachidonic acid and prostanoids of the two-ene series. We tested the effects of linoleic acid on plasma arachidonic acid, blood pressure, blood viscosity, and RBC cation transport. Oleic acid, the major dietary monounsaturated fat and which is not a prostanoid precursor, was used as a control. Seventeen adults consumed 23 g/d of linoleic acid or oleic acid provided by genetic variants of safflower seed, each for 4 weeks in a double-blind crossover design. Linoleic and oleic acids were enriched significantly in the plasma cholesteryl esters, phospholipids and triglycerides during the respective periods of supplementation but there was no increase in arachidonate. Mean BP was 116.1/76.8 during ingestion of oleic and 113.6/74.6 during ingestion of linoleic acid (p = 0.09 systolic, p = 0.12 diastolic). The power of the study was over 75% for detecting a significant (p less than 0.05) effect of 4 mm Hg in systolic BP or diastolic BP. Whole blood and plasma viscosity, and RBC Li/Na countertransport, Na/K cotransport, and Na pump systems (Vmax) were unchanged during the protocol. Therefore, variations in dietary linoleic or oleic acids are unlikely to have major effects on BP or on several membrane-dependent erythrocyte functions related to hypertension.