First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice
First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice
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DOI：
10.1097/00001756-200102120-00038
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发表时间：
2001-02-12
期刊：
影响因子：
1.7
通讯作者：
Piérard, C
中科院分区：
文献类型：
--
作者：
Béracochéa, D;Cagnard, B;Piérard, C
本研究探讨了预先注射莫达非尼对C57 BI/6小鼠延迟自发交替频率（SA）的影响。在第一个实验中，与对照组相比，64 mg/kg剂量的全身莫达非尼（而不是8 mg/kg或32 mg/kg剂量）引起交替评分（试验间隔（ITI）60 s）显著增加。在第二个实验中，莫达非尼（64 mg/kg）主要在长时间（60 s和180 s），但不是在短时间（5 s）ITI的交替率提高。莫达非尼给药未改变四孔板装置中的探索性潜伏期和活动。这些实验首次证明了莫达非尼的延迟依赖性工作记忆增强效应。NeuroReport 12：375-378（C）2001 Lippincott威廉姆斯和威尔金斯。
This study investigated the effects of pretest injection of modafinil on delayed spontaneous alternation rates (SA) used to evaluate working memory in C57 BI/6 mice. In a first experiment, systemic modafinil at 64 mg/kg, but not at 8 mg/kg or 32 mg/kg doses produced a significant increase of alternation scores (intertrial interval (ITI) 60s) when compared with controls. In a second experiment, modafinil (64 mg/kg) enhanced the alternation rates mainly at long (60 s and 180 s) but not at short (5s) ITIs. Exploratory latencies and activity in a four hole-board apparatus were not modified by modafinil administration. These experiments are the first to demonstrate a delay-dependent working memory-enhancing effect of modafinil. NeuroReport 12:375-378 (C) 2001 Lippincott Williams & Wilkins.