Volumetric Real-Time Tracking of Peripheral Human Vasculature With GPU-Accelerated Three-Dimensional Optoacoustic Tomography
Volumetric Real-Time Tracking of Peripheral Human Vasculature With GPU-Accelerated Three-Dimensional Optoacoustic Tomography
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DOI：
10.1109/tmi.2013.2272079
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发表时间：
2013-11-01
影响因子：
10.6
通讯作者：
Razansky, Daniel
中科院分区：
文献类型：
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作者：
Dean-Ben, X. Luis;Ozbek, Ali;Razansky, Daniel
光声断层成像提供了一种独特的超高速三维成像的可能性，它通过单个纳秒激光脉冲从组织的询问中获取完整的体积数据集。然而，与超声相似，光声学是一种时间分辨成像方法，因此，快速三维成像意味着同时从数百个探测器实时采集和处理高速数据，这带来了巨大的技术挑战。在这里，我们提出了一个高效的图形处理单元(GPU)框架，用于实时重建和可视化三维层析光声数据。通过利用最新开发的三维光声扫描仪，利用手持256元球面超声阵列系统同时采集信号，我们进一步展示了以每秒10个体积帧的速度跟踪人体深层组织血管的速度。手持硬件设计提供的灵活性，结合实时操作，使所开发的平台高度适用于临床成像实践和小动物研究应用。
Optoacoustic tomography provides a unique possibility for ultra-high-speed 3-D imaging by acquiring complete volumetric datasets from interrogation of tissue by a single nanosecond-duration laser pulse. Yet, similarly to ultrasound, optoacoustics is a time-resolved imaging method, thus, fast 3-D imaging implies real-time acquisition and processing of high speed data from hundreds of detectors simultaneously, which presents significant technological challenges. Herein we present a highly efficient graphical processing unit (GPU) framework for real-time reconstruction and visualization of 3-D tomographic optoacoustic data. By utilizing a newly developed 3-D optoacoustic scanner, which simultaneously acquires signals with a handheld 256-element spherical ultrasonic array system, we further demonstrate tracking of deep tissue human vasculature rendered at a rate of 10 volumetric frames per second. The flexibility provided by the handheld hardware design, combined with the real-time operation, makes the developed platform highly usable for both clinical imaging practice and small animal research applications.