Curcumin attenuates staphylococcus aureus-induced acute lung injury
Curcumin attenuates staphylococcus aureus-induced acute lung injury
复制标题
姜黄素减轻金黄色葡萄球菌引起的急性肺损伤
DOI：
10.1111/crj.12113
复制
发表时间：
2015-01-01
影响因子：
1.7
通讯作者：
Shi，Liyun
中科院分区：
文献类型：
--
作者：
Xu，Feng;Diao，Ran;Shi，Liyun
姜黄素具有显著的抗炎和抗氧化特性。目的探讨姜黄素对金黄色葡萄球菌（Staphylococcus aureus）诱导的急性肺损伤（acute lung injury，ALI）小鼠模型的保护作用。记录感染后的存活率和细菌负荷。感染后12 h处死小鼠，分析肺炎的严重程度、肺屏障的完整性、凝血级联障碍和炎症程度。在肺和支气管肺泡灌洗液中的促炎细胞因子和趋化因子的生产detected.ResultsPretreatment与姜黄素显着attenuatedS. aureus诱导的肺炎，屏障破坏，肺水肿和血管渗漏。姜黄素可降低纤溶酶原激活物抑制剂-1的活化和中性粒细胞的浸润，同时降低促炎细胞因子和趋化因子的水平。结论姜黄素可通过多种途径抑制金黄色葡萄球菌诱导的ALI。
IntroductionCurcumin has remarkable anti‐inflammatory and antioxidant properties. However, its effects on bacterium‐induced acute lung injury (ALI) are not fully understood.ObjectiveTo investigate the protective effects of curcumin on a mouse model ofS. aureus‐induced ALI.MethodsMice were pretreated with intraperitoneal injection of curcumin or vehicle 2 h beforeStaphylococcus aureusinstillation. The survival rate and bacterial burden after infection were recorded. Mice were sacrificed for the analyses of severity of pneumonia, integrity of lung barrier, disorder of coagulation cascades and extent of inflammation 12 h postinfection. The production of proinflammatory cytokines and chemokines in the lung and bronchoalveolar lavage fluid was detected.ResultsPretreatment with curcumin markedly attenuatedS. aureus‐induced pneumonia, barrier disruption, lung edema and vascular leakage. Activation of plasminogen activator inhibitor‐1 and infiltration of neutrophils were reduced by curcumin, together with lower levels of proinflammatory cytokines and chemokines.ConclusionCurcumin can alleviateS. aureus‐induced ALI through multiple pathways.