Correlation between myocardial fibrosis and restrictive cardiac physiology in patients undergoing retransplantation
Correlation between myocardial fibrosis and restrictive cardiac physiology in patients undergoing retransplantation
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DOI：
10.1111/ctr.12250
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发表时间：
2013-11-01
影响因子：
2.1
通讯作者：
Fishbein, Michael C.
中科院分区：
文献类型：
--
作者：
Kobashigawa, Jon A.;Itagaki, Brandon K.;Fishbein, Michael C.
心脏移植后，经常出现限制性心脏生理学的发展。对于导致这种生理学的因素及其与病理学的相关性，人们知之甚少。心脏再移植为进一步了解这种关系提供了宝贵的机会。在这项研究中，我们利用我们中心所有再移植的数据研究了心肌纤维化和限制性生理学的相关性，以及可能的危险因素。对 1994 年至 2004 年间在我们机构接受再移植的 30 例患者进行了回顾性分析。审查血流动力学和影像学数据是否存在限制性生理学。对病理报告进行了审查，以确定移植心脏中是否存在心肌纤维化。与非限制性生理组相比，重做心脏移植前具有限制性生理学的队列中有更多患者表现出心肌纤维化（94.1% vs. 15.4%，p
After cardiac transplant, there is often development of restrictive cardiac physiology. Little is known about the factors that contribute to this physiology and its correlation with pathology. Heart retransplantation provides a valuable opportunity to further understand this relationship. In this study, we investigated the correlation of myocardial fibrosis and restrictive physiology, and possible risk factors utilizing data from all retransplants at our center. A retrospective review of the 30 patients who underwent retransplantation at our institution between 1994 and 2004 was performed. Hemodynamic and imaging data were reviewed for the presence of restrictive physiology. Pathology reports were reviewed for the presence of myocardial fibrosis in the explanted hearts. The cohort with restrictive physiology preceding redo heart transplant had significantly more patients exhibiting myocardial fibrosis compared with the non-restrictive physiology group (94.1% vs. 15.4%, p