Plasma Carbonic Anhydrase II protein is Elevated in Alzheimer's Disease
Plasma Carbonic Anhydrase II protein is Elevated in Alzheimer's Disease
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DOI：
10.3233/jad-2010-100384
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发表时间：
2010-01-01
影响因子：
4
通讯作者：
Koh, Young Ho
中科院分区：
文献类型：
--
作者：
Jang, Bong Geom;Yun, Sang-Moon;Koh, Young Ho
碳酸酐酶（Carbonic anhydrase，CA）在pH调节、长时程突触转化中起关键作用，与智力低下、阿尔茨海默病（Alzheimer's disease，AD）和唐氏综合征（Down syndrome）有关。越来越多的证据表明，AD脑中CAII增加。本研究采用免疫印迹法和酶联免疫吸附法测定血浆中CAII蛋白水平。我们比较了91例AD患者（平均年龄74.8岁）、83例遗忘型轻度认知障碍（MCI）患者（平均年龄73.7岁）和113例认知正常对照者（平均年龄70.8岁）的血浆。与对照组相比，AD患者的血浆CAII水平显著升高。男性的CAII水平高于女性。有一个年龄依赖性的增加CAII。这些结果进一步证明，CAII水平的变化可能在AD的发病机制中发挥作用。
Carbonic anhydrase (CA) plays a critical role in pH regulation, long-term synaptic transformation, and is associated with mental retardation, Alzheimer's disease (AD), and Down syndrome. There is accumulating evidence that CAII is increased in AD brain. The present study focused on the determination of CAII protein level in blood plasma samples using immunoblot and ELISA methods. We compared plasma from 91 AD patients (average age 74.8 y), 83 persons with amnestic mild cognitive impairment (MCI) (average age 73.7 y), and 113 cognitively normal controls (average age 70.8 y). The plasma level of CAII was significantly increased in AD patients, as compared to control groups. CAII levels were higher in males than females. There was an age-dependent increase of CAII. These results provide further evidence that changes in CAII level may play a role in the pathogenesis of AD.