Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators.
Plasticity of leukocytic exudates in resolving acute inflammation is regulated by MicroRNA and proresolving mediators.
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在解决急性炎症中的白细胞渗出液的可塑性受microRNA和介导子的调节。
DOI：
10.1016/j.immuni.2013.10.011
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发表时间：
2013-11-14
期刊：
影响因子：
32.4
通讯作者：
Serhan, Charles N.
中科院分区：
文献类型：
--
作者：
Li, Yongsheng;Dalli, Jesmond;Chiang, Nan;Baron, Rebecca M.;Quintana, Carolina;Serhan, Charles N.
急性炎症的程度和持续时间由涉及专门的前消退介质（SPM;消退素和maresins）和microRNA（miRNA）的主动消退程序控制。在这里，我们报告说，miR-466 l在小鼠渗出液浸润白细胞的时间调节。在体内，Neu miR-466 l过表达促进了炎症的发生，而炎症的发生先于巨噬细胞表达该miRNA，当过表达时，该miRNA加速了炎症的消退。在巨噬细胞中，miR-466 l过表达增加了前列腺素和SPM（例如，Resolvin D1 [RvD 1]和RvD 5），这增强了分辨率。RvD 1、RvD 2、maresin 1（MaR 1）和凋亡中性粒细胞减少了人巨噬细胞内的miR-466 l表达，这是一种最有可能为稳态做准备的反馈调节。miR-466 l在脓毒症患者的外周血中上调，并且其增加与脓毒症的非存活相关。SPM和miR-466 l在miRNA生物合成中调节转录因子激活蛋白1和核因子κB1。这些结果证明SPM和miR-466 l在急性炎症反应消退期间在动态白细胞可塑性中的关键作用。
The magnitude and duration of acute inflammation are controlled by active resolution programs involving specialized proresolving mediators (SPMs; resolvins and maresins) and microRNAs (miRNAs). Here, we report that miR-466l was temporally regulated in murine exudate-infiltrating leukocytes. Neutrophil miR-466l overexpression in vivo promoted initiation of inflammation that anteceded macrophage expression of this miRNA, which accelerated resolution when overexpressed. In macrophages, miR-466l overexpression increased prostanoids and SPMs (e.g., resolvin D1 [RvD1] and RvD5), which enhanced resolution. RvD1, RvD2, maresin 1 (MaR1), and apoptotic neutrophils reduced miR-466l expression within human macrophages, a feedback regulation that most likely prepares for homeostasis. miR-466l was upregulated in peripheral blood of sepsis patients, and its increase correlated with nonsurvival from sepsis. SPMs and miR-466l regulated transcription factors activator protein 1 and nuclear factor κB1 in miRNA biogenesis. These results demonstrate pivotal roles for SPMs and miR-466l in dynamic leukocyte plasticity during resolution of acute inflammatory responses.
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影响因子：
64.8
作者：
Chiang, Nan;Fredman, Gabrielle;Backhed, Fredrik;Oh, Sungwhan F.;Vickery, Thad;Schmidt, Birgitta A.;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
DOI：
10.1073/pnas.1206641109
发表时间：
2012-09-11
影响因子：
11.1
作者：
El Kebir, Driss;Gjorstrup, Per;Filep, Janos G.
通讯作者：
Filep, Janos G.
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4.6
作者：
Fredman, Gabrielle;Li, Yongsheng;Dalli, Jesmond;Chiang, Nan;Serhan, Charles N.
通讯作者：
Serhan, Charles N.
影响因子：
4.4
作者：
Bannenberg, GL;Chiang, N;Serhan, CN
通讯作者：
Serhan, CN