Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers
Worldwide Trends in Incidence Rates for Oral Cavity and Oropharyngeal Cancers
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DOI：
10.1200/jco.2013.50.3870
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发表时间：
2013-12-20
影响因子：
45.3
通讯作者：
Gillison, Maura L.
中科院分区：
文献类型：
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作者：
Chaturvedi, Anil K.;Anderson, William F.;Gillison, Maura L.
目的人乳头瘤病毒（HPV）已被确定为一些国家口咽癌（OPC）发病率上升的原因。为了研究这是否代表一种全球现象，我们评估了四大洲23个国家的外阴癌和口腔癌（OCCs）的发病率趋势。方法：我们使用来自五大洲癌症发病率数据库第六卷至第九卷（1983年至2002年）的数据。使用年龄-时期-队列模型，将OPCs的发病率趋势与OCCs和肺癌的发病率趋势进行比较，以描述HPV相对于吸烟对发病率趋势的潜在作用。分析是针对国家和性别的。结果1983 ~ 2002年OPC发病率显著上升，主要发生在经济发达国家。在男性中，美国、澳大利亚、加拿大、日本和斯洛伐克的OPC发病率显著增加，尽管occ发病率无显著或显著下降。相反，在妇女中，在所有OPC发病率增加的国家（丹麦、爱沙尼亚、法国、荷兰、波兰、斯洛伐克、瑞士和联合王国），occ的发病率也随之增加。虽然男性的OPC发病率增加伴随着肺癌发病率的下降，但女性的发病率增加通常伴随着肺癌发病率的增加。在美国、澳大利亚、加拿大、斯洛伐克、丹麦和英国，年轻男性（< 60岁）OPC发病率的增加幅度明显高于老年男性。结论1983 ~ 2002年OPC发病率显著上升，主要发生在发达国家和低龄人群。这些结果强调了HPV感染增加OPC发病率的潜在作用，特别是在男性中。
Purpose Human papillomavirus (HPV) has been identified as the cause of the increasing oropharyngeal cancer (OPC) incidence in some countries. To investigate whether this represents a global phenomenon, we evaluated incidence trends for OPCs and oral cavity cancers (OCCs) in 23 countries across four continents.Methods We used data from the Cancer Incidence in Five Continents database Volumes VI to IX (years 1983 to 2002). Using age-period-cohort modeling, incidence trends for OPCs were compared with those of OCCs and lung cancers to delineate the potential role of HPV vis-a-vis smoking on incidence trends. Analyses were country specific and sex specific.Results OPC incidence significantly increased during 1983 to 2002 predominantly in economically developed countries. Among men, OPC incidence significantly increased in the United States, Australia, Canada, Japan, and Slovakia, despite nonsignificant or significantly decreasing incidence of OCCs. In contrast, among women, in all countries with increasing OPC incidence (Denmark, Estonia, France, the Netherlands, Poland, Slovakia, Switzerland, and United Kingdom), there was a concomitant increase in incidence of OCCs. Although increasing OPC incidence among men was accompanied by decreasing lung cancer incidence, increasing incidence among women was generally accompanied by increasing lung cancer incidence. The magnitude of increase in OPC incidence among men was significantly higher at younger ages (< 60 years) than older ages in the United States, Australia, Canada, Slovakia, Denmark, and United Kingdom.Conclusion OPC incidence significantly increased during 1983 to 2002 predominantly in developed countries and at younger ages. These results underscore a potential role for HPV infection on increasing OPC incidence, particularly among men.