Interleukin-1 effect on glycemia in the non-obese diabetic mouse at the pre-diabetic stage
Interleukin-1 effect on glycemia in the non-obese diabetic mouse at the pre-diabetic stage
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DOI：
10.1677/joe.0.1480139
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发表时间：
1996-01-01
影响因子：
4
通讯作者：
HomoDelarche, F
中科院分区：
文献类型：
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作者：
Amrani, A;JafarianTehrani, M;HomoDelarche, F
细胞因子，特别是白细胞介素1（IL-1）和肿瘤坏死因子，已知在正常啮齿类动物或不同的II型糖尿病实验模型中诱导低血糖。我们研究了在糖尿病前期，短期给予小鼠重组白细胞介素-1 α（mrIL-1 α）对非肥胖糖尿病（NOD）小鼠（一种自发性I型糖尿病模型）血糖、胰岛素和皮质酮水平的影响。两个月大的糖尿病前期NOD小鼠（两种性别）在给药后2小时对mrIL-1 α（12.5和50 μ g/kg）不敏感，在C57 BL/6小鼠品系中观察到最大降低（约50%）的时间。然而，动力学研究表明，mrIL-1 α降低了NOD小鼠两种性别的rIL-1，但效果有限且延迟。在NOD和C57 BL/6品系中，mrIL-1 α对雌性大鼠的胰岛素水平无影响，但可显著升高雄性大鼠的胰岛素水平（P <0.05）。
Cytokines, particularly interleukin 1 (IL-1) and tumor necrosis factor, are known to induce hypoglycemia in normal rodents or different experimental models oftype II diabetes. We investigated, at the pre-diabetic stage, the effect of short-term administration of murine recombinant interleukin-1 alpha (mrIL-1 alpha) on the levels of glucose, insulin and corticosterone in the non-obese diabetic (NOD) mouse, a spontaneous model of type I diabetes. Two-month-old, pre-diabetic NOD mice of both sexes were insensitive to mrIL-1 alpha (12.5 and 50 mu g/kg) 2 h after administration, the time at which the maximal decrease (around 50%) was observed in the C57BL/6 mouse strain. Kinetic studies however showed that mrIL-1 alpha lowered glycemia in both sexes of NOD mice, but the effect was limited and delayed. In the NOD and C57BL/6 strains, mrIL-1 alpha had no influence on insulin levels in females, but significantly increased them in males (P