THE COOMBS DIRECT ANTIGLOBULIN-TEST IN KENYANS
THE COOMBS DIRECT ANTIGLOBULIN-TEST IN KENYANS
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DOI：
10.1016/0035-9203(83)90028-7
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发表时间：
1983-01-01
影响因子：
2.2
通讯作者：
WEATHERALL, DJ
中科院分区：
文献类型：
--
作者：
ABDALLA, SH;KASILI, FG;WEATHERALL, DJ
对肯尼亚243名受试者进行了直接抗球蛋白试验（DAT）。在疟疾儿童中，DAT阳性的发生率很高，其中70%的儿童红细胞分别或一起包被IgG、C3和C4。只有12%患有疟疾以外疾病的儿科患者的DAT呈阳性。大多数与疟疾相关的dat阳性病例发生在18个月至5岁的儿童中。来自疟疾低传播地区的基库尤儿童的DAT阳性发生率低于居住在疟疾高流行地区的其他部落群体的儿童。在内脏利什曼病患者中，DAT阳性率也很高。有趣的是，五名内脏利什曼病患者和两名来自内脏利什曼病流行地区的学童的红细胞中IgG和C4有关联，但没有C3。在其他患者中没有发现这种组合。
The direct antiglobulin test (DAT) was performed on 243 subjects in Kenya. A high incidence of positive DAT was found in children with malaria of whom 70% had RBCs coated with IgG, C3 and C4 either separately or together. Only 12% of paediatric patients with conditions other than malaria had a positive DAT. Most positive DATs in association with malaria occurred in children between 18 months and five years of age.There was a lower incidence of positive DAT in Kikuyu children from an area of low malarial transmission than in children from other tribal groups who reside in areas of high malaria endemicity.A high rate of positive DAT was also found in patients with visceral leishmaniasis. Interestingly there was an association of IgG and C4 but without C3 on red cells of five patients with visceral leishmaniasis and two schoolchildren from an area endemic for visceral leishmaniasis. This combination was not found in other patients.