LAMELLAR GRANULES IN MAMMALIAN, AVIAN, AND REPTILLIAN EPIDERMIS
LAMELLAR GRANULES IN MAMMALIAN, AVIAN, AND REPTILLIAN EPIDERMIS
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DOI：
10.1016/s0022-5320(80)90062-3
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
LANDMANN, L
中科院分区：
文献类型：
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作者：
LANDMANN, L
有证据表明，哺乳动物的膜覆盖颗粒（来自新生小鼠）、鸟类的多颗粒体（来自鸡）和爬行动物的中膜颗粒（来自草蛇，Natrix Natrix）是同源结构。这三种类型在这里被称为片层状颗粒，它们有以下共同点：由像硬币一样叠在一起的圆盘产生的层状图案，将相邻的圆盘分开的主要致密线，每个磁盘都包含一个次要致密线，主要致密线之间的间距和厚度，与各种脂质染色呈正反应，周期性酸希夫和Thiery Ag法，用脂质溶剂或磷脂酶C处理后层状图案消失。将内容物挤压到细胞间隙并重新排列成与角质层细胞表面平行的宽片。根据这些观察和先前的生化结果，层状内容物（圆盘）被解释为扁平的脂质体。
Evidence is presented that mammalian membrane-coating granules [from neonatal mice] avian multigranular bodies [from chicken] and reptilian mesos granules [from grass snake, Natrix natrix] are homologous structures. All 3 types, which will here be called lamellar granules, have the following items in common: a lamellar pattern produced by disks stacked coin-like above each other, major dense lines separating adjacent disks, each of which contains a minor dense line, spacing between and thickness of major dense lines, positive reaction with various lipid stains, periodic acid-Schiff and the Thiery Ag method, disappearance of the lamellar pattern after treatment with lipid solvents or phospholipase C, and extrusion of contents into the intercellular space and its rearrangement into broad sheets running parallel to the surface of the horny cells. Based on these obseervations and previous biochemical results, the lamellar contents (disks) are interpreted as flattened liposomes.