Substrate metabolism during different exercise intensities in endurance-trained women
Substrate metabolism during different exercise intensities in endurance-trained women
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DOI：
10.1152/jappl.2000.88.5.1707
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发表时间：
2000-05-01
影响因子：
3.3
通讯作者：
Wolfe, RR
中科院分区：
文献类型：
--
作者：
Romijn, JA;Coyle, EF;Wolfe, RR
我们研究了8名接受过耐力训练的女性，她们在休息时和运动时分别处于最大摄氧量的25%、65%和85%。游离脂肪酸（FFA）的出现率（R-a）通过[H-2（2）]棕榈酸酯的输注来测定，脂肪氧化率通过间接量热法来测定。用[6，6-H-2（2）]葡萄糖评估葡萄糖动力学。葡萄糖R-α的增加与运动强度有关。相反，而FFA R-a显着增加到相同程度的低强度和中等强度的运动，在高强度的运动，FFA R-a降低与其他运动值相比。碳水化合物氧化随着运动强度的增加而逐渐增加，而脂肪氧化的最高速率是在运动期间最大摄氧量的65%。在对瘦体重差异进行校正后，这些结果与之前报道的在相同条件下研究的接受过耐力训练的男性的数据之间没有差异，除了低强度运动期间葡萄糖代谢的轻微差异（Romijn JA，Coyle EE，Sidossis LS，Gastaldelli A，Horowitz JF，Endert E和Wolfe RR。Am J Physiol Endocrinol Metab 265：E380-E391，1993）。我们的结论是，在中等强度和高强度的运动过程中，底物动力学的变化模式是相似的，在训练有素的男性和女性。
We have studied eight endurance-trained women at rest and during exercise at 25, 65, and 85% of maximal oxygen uptake. The rate of appearance (R-a) of free fatty acids (FFA) was determined by infusion of [H-2(2)]palmitate, and fat oxidation rates were determined by indirect calorimetry. Glucose kinetics were assessed with [6,6-H-2(2)]glucose. Glucose R-a increased in relation to exercise intensity. In contrast, whereas FFA R-a was significantly increased to the same extent in low- and moderate-intensity exercise, during high-intensity exercise, FFA R-a was reduced compared with the other exercise values. Carbohydrate oxidation increased progressively with exercise intensity, whereas the highest rate of fat oxidation was during exercise at 65% of maximal oxygen uptake. After correction for differences in lean body mass, there were no differences between these results and previously reported data in endurance-trained men studied under the same conditions, except for slight differences in glucose metabolism during low-intensity exercise (Romijn JA, Coyle EE, Sidossis LS, Gastaldelli A, Horowitz JF, Endert E, and Wolfe RR. Am J Physiol Endocrinol Metab 265: E380-E391, 1993). We conclude that the patterns of changes in substrate kinetics during moderate- and high-intensity exercise are similar in trained men and women.