Prognostic role of cyclin B1 in solid tumors: a meta-analysis.
Prognostic role of cyclin B1 in solid tumors: a meta-analysis.
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细胞周期蛋白 B1 在实体瘤中的预后作用：荟萃分析。
DOI：
10.18632/oncotarget.13653
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发表时间：
2017-01-10
期刊：
影响因子：
--
通讯作者：
Chai Y
中科院分区：
文献类型：
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作者：
Ye C;Wang J;Wu P;Li X;Chai Y
细胞周期蛋白B1是细胞周期G2-M期转变过程中的关键有丝分裂蛋白，在多种恶性肿瘤中均有过表达。大量研究报道了细胞周期蛋白B1在人类实体瘤中的表达与预后之间的相互矛盾的证据。为了解决这一差异，我们对来自PubMed和Medline的17项已发表研究进行了荟萃分析。Cyclin B1过表达与实体瘤3年总生存率(OR=2.0 5，95%CI=1.2 0~3.5 0，P=0.009)和5年OS(OR=2.11，95%CI=1.3 3~3.36，P=0.002)显著相关。亚组分析显示，Cyclin B1高表达与肺癌、食道癌预后差有关，而与结直肠癌预后好相关。综上所述，在大多数实体瘤中，细胞周期蛋白B1的过度表达与生存不良有关，这表明细胞周期蛋白B1的表达状态是实体肿瘤中一个重要的预后参数。
Cyclin B1 is a key mitotic cyclin in the G2-M phase transition of the cell cycle and is overexpressed in various malignant tumors. Numerous studies have reported contradictory evidences of the correlation between cyclin B1 expression and prognosis in human solid tumors. To address this discrepancy, we conducted a meta-analysis with 17 published studies searched from PubMed and Medline. Cyclin B1 overexpression was significantly associated with poor 3-year overall survival (OS) (OR = 2.05, 95% CI = 1.20 to 3.50, P = 0.009) and 5-year OS (OR = 2.11, 95% CI = 1.33 to 3.36, P = 0.002) of solid tumors. Subgroup analysis revealed that elevated cyclin B1 expression was associated with worse prognosis of lung cancer and esophageal cancer but better prognosis of colorectal cancer. In summary, overexpression of cyclin B1 is correlated with poor survival in most solid tumors, which suggests that the expression status of cyclin B1 is a significant prognostic parameter in solid tumors.