EXPOSURE TO ORGANIC-SOLVENTS AND HYPERTENSIVE DISORDERS OF PREGNANCY
EXPOSURE TO ORGANIC-SOLVENTS AND HYPERTENSIVE DISORDERS OF PREGNANCY
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DOI：
10.1002/ajim.4700140208
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发表时间：
1988-01-01
影响因子：
3.5
通讯作者：
GRADY, J
中科院分区：
文献类型：
--
作者：
ESKENAZI, B;BRACKEN, MB;GRADY, J
本研究比较了90名孕期接触不同有机溶剂的妇女和180名未接触有机溶剂(2：1)的受试者的不良妊娠并发症的发生率和结局。接触溶剂的妇女患先兆子痫的可能性大约是后者的四倍，这是一种以高血压、浮肿和蛋白尿为特征的妊娠障碍(无条件调整后的RR=3.9，95%CI=2.5，5.4)。单独的高血压，没有水肿或蛋白尿，也更有可能在接触溶剂的妇女中报告(无条件调整的RR=3.0，95%CI=0.9，9.9)为溶剂暴露与妊娠高血压疾病的关联提供了额外的支持。由于先兆子痫被认为主要与肾小球病变有关，我们的发现，尽管需要更大的样本量来复制，但考虑到越来越多的文献将溶剂暴露与肾脏疾病联系起来，我们的发现在生物学上可能是可信的。接触溶剂的妇女更有可能出现心血管并发症，并通过剖腹产分娩；然而，考虑到特定类型的并发症和剖腹产的原因，这些发现不太可能与溶剂暴露直接相关。其他妊娠并发症，如先兆流产和阴道出血，以及新生儿生长发育和成熟度差，在暴露组中并不常见。
The present investigation compares the frequency of adverse pregnancy complications and outcomes in 90 women who worked with various organic solvents during pregnancy and in 180 unexposed matched (2:1) subjects. Solvent-exposed women were approximately four times more likely to develop preeclampsia, a disorder of pregnancy characterized by hypertension, edema, and proteinuria (unconditional adjusted RR = 3.9, 95% CI = 2.5, 5.4). That hypertension alone, without edema or proteinuria, was also more likely to be reported in solvent-exposed women (unconditional adjusted RR = 3.0, 95% CI = 0.9, 9.9) lent additional support to the association of solvent exposure and hypertensive disorders of pregnancy. Because preeclampsia is thought to be associated primarily with glomerular lesions, our findings, although in need of replication with a larger sample size, may be biologically plausible given the growing literature associating solvent exposure with renal disease. Solvent-exposed women were more likely to have cardiovascular complications and to deliver by cesarean section; however, given the specific type of complications and reason for cesarean, it is unlikely that these findings were directly related to solvent exposure. Other pregnancy complications such as threatened abortion and vaginal bleeding, and poor neonatal growth and maturity, were not more common in the exposed group.