Properties of glycolipid-enriched membrane rafts in antigen presentation.
Properties of glycolipid-enriched membrane rafts in antigen presentation.
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DOI：
10.1615/critrevimmunol.v25.i1.20
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发表时间：
2005
影响因子：
1.3
通讯作者：
W. Rodgers;Kenneth Smith
中科院分区：
文献类型：
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作者：
W. Rodgers;Kenneth Smith
向 T 细胞呈递抗原代表免疫系统参与防御宿主抵抗病原体的核心事件之一。因此，了解抗原呈递发生的机制对于我们了解宿主对外来抗原的防御特性以及深入了解免疫系统的其他特征（例如自身免疫性疾病）至关重要。整个抗原呈递事件非常复杂，并且其许多特征仍然知之甚少。然而，最近的研究提供的证据表明，富含糖脂的膜筏对于有效的抗原呈递很重要；研究表明，筏的其中一项功能是将抗原-MHC II 复合物运输到抗原呈递细胞表面的呈递位点。在这里，我们对筏及其在抗原呈递中的拟议功能进行了批判性讨论。还强调了值得进一步研究的筏和抗原呈递的新兴主题。
Presentation of antigen to T cells represents one of the central events in the engagement of the immune system toward the defense of the host against pathogens. Accordingly, understanding the mechanisms by which antigen presentation occurs is critical toward our understanding the properties of host defense against foreign antigen, as well as insight into other features of the immune system, such as autoimmune disease. The entire antigen-presentation event is complex, and many features of it remain poorly understood. However, recent studies have provided evidence showing that glycolipid-enriched membrane rafts are important for efficient antigen presentation; the studies suggest that one such function of rafts is trafficking of antigen-MHC II complexes to the presentation site on the surface of the antigen-presenting cell. Here, we present a critical discussion of rafts and their proposed functions in antigen presentation. Emerging topics of rafts and antigen presentation that warrant further investigation are also highlighted.