Chronic administration of low doses of adrenocorticotropin to hypophysectomized fetal sheep leads to normal term labor.
Chronic administration of low doses of adrenocorticotropin to hypophysectomized fetal sheep leads to normal term labor.
复制标题
对垂体切除的胎羊长期给予低剂量的促肾上腺皮质激素可导致正常足月分娩。
DOI：
10.1210/endo.134.3.8119178
复制
发表时间：
1994
期刊：
影响因子：
4.8
通讯作者：
G. Thorburn
中科院分区：
文献类型：
--
作者：
R. A. Jacobs;I. Young;S A Hollingworth;G. Thorburn
Parturition in the sheep is preceded by an increase in the plasma concentration of fetal ACTH and an increase in the plasma cortisol concentration. The role and importance of the increase in fetal ACTH in stimulating fetal glucocorticoid synthesis and the subsequent onset of labor require closer examination, as it has been demonstrated that the fetal adrenal becomes more responsive to ACTH in late gestation. This study sets out to determine whether the increase in plasma ACTH in the late gestation fetal sheep is essential for maturation of the fetal adrenal gland and normal delivery. Fetal sheep were either hypophysectomized (HX) and cannulated or cannulated only (intact) at 125 days gestation. Immediately after surgery, HX fetuses were infused with a constant dose of ACTH-(1-24) (ACTH/HX; 100 ng/h.kg, i.v.) or saline (SAL/HX) until uterine electromyography indicated the onset of labor or 161 days gestation was reached (term = 147 +/- 2.6 days). The mean gestational age at labor of the ACTH/HX group was 147 +/- 2.9 days, whereas none of the animals in the SAL/HX entered labor, and they were killed at 161 days gestation. The concentration of ACTH in both ACTH/HX and SAL/HX fetal plasma was less than 2.2 pg/ml throughout the study. The concentration of cortisol in ACTH/HX fetuses mimicked that in intact fetuses in late gestation, reaching 80 ng/ml at term. The concentration of cortisol in SAL/HX fetuses remained less than 5 ng/ml. This study supports the hypothesis that the ovine fetal adrenal becomes increasingly responsive to ACTH in late gestation and indicates that ACTH may only be permissive in the activation of adrenal function. In intact fetal sheep there may be endogenous inhibition of the fetal adrenal, requiring relatively high plasma concentrations of ACTH [100-250 pg/ml ACTH-(1-39)] in late gestation.
羊胎儿肾上腺皮质醇的合成：促肾上腺皮质激素、血管紧张素 II 和转化生长因子-β 的调节。
影响因子：
4.8
作者：
Rainey,WE;Oka,K;Magness,RR;Mason,JI
通讯作者：
Mason,JI
绵羊胎盘类固醇 17 α-羟化酶/C-17,20-裂解酶、芳香酶和硫酸酯酶在地塞米松诱导和自然分娩中的作用。
DOI：
10.1677/joe.0.1220351
发表时间：
1989
期刊：
The Journal of endocrinology
影响因子：
--
作者：
Mason,JI;France,JT;Magness,RR;Murry,BA;Rosenfeld,CR
通讯作者：
Rosenfeld,CR
妊娠晚期羔羊胎儿肾上腺对促肾上腺皮质激素（1-24）敏感性增加的体内证据。
影响因子：
4.8
作者：
Rose,JC;Meis,PJ;Urban,RR;GreissJr,FC
通讯作者：
GreissJr,FC