Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging.
Vascular Regulation of Hematopoietic Stem Cell Homeostasis, Regeneration, and Aging.
复制标题
DOI：
10.1007/s40778-021-00198-2
复制
发表时间：
2021
影响因子：
1.4
通讯作者：
Poulos MG
中科院分区：
文献类型：
--
作者：
Ramalingam P;Butler JM;Poulos MG
造血干细胞（HSC）位于细胞层级的顶端，承担着日常血液生产的负担。 HSC 的维持依赖于骨髓 (BM) 微环境的外在线索来平衡干细胞自我更新和细胞命运决定。在这篇简短的综述中，我们将重点介绍定义 BM 血管内皮在健康和压力调节 HSC 活性中的集中作用的研究和模型系统。骨髓微环境由多种密切相关的血管和血管周围细胞类型组成。最近的动态成像研究，结合单细胞 RNA 测序 (scRNA-seq) 和功能读数，加深了我们对 HSC 支持细胞类型及其在稳态、再生和衰老过程中控制干细胞命运的合作机制的理解。这些发现在 BM 内建立了复杂且离散的血管微环境，表达了调节 HSC 命运的重叠且独特的旁分泌信号。了解 HSC-微环境的空间和相互相互作用以及控制 BM 血管微环境中 HSC 活性的分子机制对于开发旨在改善血液疾病和支持健康造血输出的疗法至关重要。
Hematopoietic stem cells (HSCs) sit at the top of the hierarchy that meets the daily burden of blood production. HSC maintenance relies on extrinsic cues from the bone marrow (BM) microenvironment to balance stem cell self-renewal and cell fate decisions. In this brief review, we will highlight the studies and model systems that define the centralized role of BM vascular endothelium in modulating HSC activity in health and stress. The BM microenvironment is composed of a diverse array of intimately associated vascular and perivascular cell types. Recent dynamic imaging studies, coupled with single-cell RNA sequencing (scRNA-seq) and functional readouts, have advanced our understanding of the HSC-supportive cell types and their cooperative mechanisms that govern stem cell fate during homeostasis, regeneration, and aging. These findings have established complex and discrete vascular microenvironments within the BM that express overlapping and unique paracrine signals that modulate HSC fate. Understanding the spatial and reciprocal HSC-niche interactions and the molecular mechanisms that govern HSC activity in the BM vascular microenvironment will be integral in developing therapies aimed at ameliorating hematological disease and supporting healthy hematopoietic output.
登录
查看更多内容
影响因子：
23.9
作者：
Butler JM;Nolan DJ;Vertes EL;Varnum-Finney B;Kobayashi H;Hooper AT;Seandel M;Shido K;White IA;Kobayashi M;Witte L;May C;Shawber C;Kimura Y;Kitajewski J;Rosenwaks Z;Bernstein ID;Rafii S
通讯作者：
Rafii S
影响因子：
64.5
作者：
Baryawno, Ninib;Przybylski, Dariusz;Scadden, David T.
通讯作者：
Scadden, David T.
影响因子：
82.9
作者：
通讯作者：
--
影响因子：
82.9
作者：
Cao Z;Lis R;Ginsberg M;Chavez D;Shido K;Rabbany SY;Fong GH;Sakmar TP;Rafii S;Ding BS
通讯作者：
Ding BS
影响因子：
21.3
作者：
Asada N;Kunisaki Y;Pierce H;Wang Z;Fernandez NF;Birbrair A;Ma'ayan A;Frenette PS
通讯作者：
Frenette PS