Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules
Structure of the Ly49 family of natural killer (NK) cell receptors and their interaction with MHC class I molecules
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DOI：
10.1385/ir:30:1:095
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发表时间：
2004-01-01
影响因子：
4.4
通讯作者：
Biassoni, R
中科院分区：
文献类型：
--
作者：
Dimasi, N;Moretta, L;Biassoni, R
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Natural killer (NK) cells are an essential component of the innate immunity toward tumors and virally infected cells. The function of NK cells is regulated by a precise balance between inhibitory and activating signals. These signals are mediated by NK cell receptors that bind either classical MHC class I molecules or their structural relatives such as MICA, ULBP, RAE-I, and H-60. Two separate families of NK cell receptors have been identified: the immunoglobulinlike family (KIR, LIR) and C-type lectin-like family (Ly49, NKG2D, and CD94/NKG2). Here we summarize the Structure of Ly49 C-type lectin-like proteins hitherto solved (Ly49A, Ly49C and Ly49I) and their interaction with MHC class I molecules as determined by the co-crystal structure of Ly49A/H-2D(d) and Ly49C/H-2K(b).