Ontological Foundations for Biology Knowledge Models

Ontological Foundations for Biology Knowledge Models
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生物学知识模型的本体论基础

DOI:
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发表时间:
1996
期刊:
Intelligent Systems in Molecular Biology
影响因子:
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通讯作者:
Natasha Noy
Natasha Noy
中科院分区:
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文献类型:
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作者:
C. Hafner;Natasha Noy

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本文分析了生物学知识表示的本体需求,并指出了当前知识表示(KR)范式需要扩展的几个领域。我们专注于实验材料和方法的表示,以及智能信息检索的推理任务;然而,我们提出的本体论问题一般适用于生物学(和实验科学)。我们已经确定了分子生物学中两种重要的概念类型,它们会给标准知识模型带来问题:1)复杂物质,如混合物和核酸序列; 2)将一种物质转化为另一种物质的转化(如生化反应)。我们描述了这些问题,提出了解决方案,其中一些,并给出了这样的知识表示在智能信息检索的需要的例子。
This paper analyzes the ontological requirements for representing biology knowledge, and identifies several areas where current knowledge representation (KR) paradigms need to be extended. We focus on the representation of experimental materials and methods, and the reasoning task of intelligent information retrieval; however, the ontological issues we raise apply to biology (and experimental sciences) in general. We have identified two important concept types in molecular biology that cause problems for standard knowledge models: 1) complex substances such as mixtures and nucleic acid sequences; 2) transformations (such as biochemical reactions) that convert one substances into another. We describe these problems, propose solutions for some of them, and given examples of the need for such knowledge representations in intelligent information retrieval.
DOI: 10.1073/pnas.88.3.750
发表时间: 1991-02-01
影响因子: 11.1
作者:
GEGNER, JA;DAHLQUIST, FW
通讯作者: DAHLQUIST, FW