Oscillatory decoupling differentiates auditory encoding deficits in children with listening problems
Oscillatory decoupling differentiates auditory encoding deficits in children with listening problems
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DOI：
10.1016/j.clinph.2015.11.003
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发表时间：
2016-02-01
影响因子：
4.7
通讯作者：
Purdy, Suzanne C.
中科院分区：
文献类型：
--
作者：
Gilley, Phillip M.;Sharma, Mridula;Purdy, Suzanne C.
目的：我们试图研究是否振荡脑电图反应的语音刺激在安静和噪音是不同的儿童听力问题比儿童听力正常。方法：我们对21名发育正常的儿童在安静和3dB信噪比下对150 ms语音/da/的皮层听觉诱发电位进行了高分辨率的频谱-时间分析（平均年龄= 10.7岁，标准差= 1.7）和44名报告听力问题（LP）但无听力损失的儿童（平均年龄= 10.3岁，标准差= 1.6）。对LP患儿进行听觉加工障碍（APD）评估，其中24例有APD，20例无APD。结果：LP患儿在θ和α频段有频率偏移（p < 0.05），LP + APD儿童的频率增加，（p < 0.01）和潜伏期偏移（p < 0.05）在上β带和下γ带中。这些结果为LP儿童的高级调制处理差异提供了证据，并且APD是由早期听觉编码差异驱动的。这些发现可能会更好地指导未来的研究，以改善这一人群的儿童听力问题的鉴别诊断和治疗。由Elsevier爱尔兰有限公司代表国际临床神经生理学联合会发布。
Objective: We sought to examine whether oscillatory EEG responses to a speech stimulus in both quiet and noise were different in children with listening problems than in children with normal hearing.Methods: We employed a high-resolution spectral-temporal analysis of the cortical auditory evoked potential in response to a 150 ms speech sound /da/ in quiet and 3 dB SNR in 21 typically developing children (mean age = 10.7 years, standard deviation = 1.7) and 44 children with reported listening problems (LP) with absence of hearing loss (mean age = 10.3 years, standard deviation = 1.6). Children with LP were assessed for auditory processing disorder (APD) by which 24 children had APD, and 20 children did not. Peak latencies, magnitudes, and frequencies were compared between these groups.Results: Children with LP had frequency shifts in the theta, and alpha bands (p < 0.05), and children with LP + APD had additional frequency (p < 0.01) and latency shifts (p < 0.05) in the upper beta and in the lower gamma bands.Conclusions: These results provide evidence for differences in higher level modulatory processing in children with LP, and that APD is driven by differences in early auditory encoding.Significance: These findings may better guide future research toward improving the differential diagnosis and treatment of listening problems in this population of children. Published by Elsevier Ireland Ltd. on behalf of International Federation of Clinical Neurophysiology.