Coronary Health Improvement Project CHIP) is associated with improved nutrient intake and decreased depression
Coronary Health Improvement Project CHIP) is associated with improved nutrient intake and decreased depression
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DOI：
10.1016/j.nut.2007.12.011
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发表时间：
2008-04-01
期刊：
影响因子：
4.4
通讯作者：
Aldana, Steven G.
中科院分区：
文献类型：
--
作者：
Merrill, Ray M.;Taylor, Penny;Aldana, Steven G.
目的：我们评估了冠状动脉健康改善项目（CHIP）在降低抑郁症的疗效修改选定的每日营养food.Methods：一个随机对照试验，与348名参与者24岁至81岁的大都会罗克福德，伊利诺伊州。参与者在基线和6周和6个月的随访时进行评估。结果：与对照组相比，干预组在6 wk时BDI下降的可能性高63%（P < 0.0001），在6 mo时BDI下降的可能性高34%（P < 0.0001）。校正年龄、性别、运动量、体重指数和运动量后，基线饱和脂肪水平与BDI呈负相关（P < 0.0001）。研究期间饱和脂肪的减少与BDI的减少直接相关。吡哆醇（B6）的增加也与BDI的降低有关。干预通过降低饱和脂肪和增加膳食吡哆醇（B6）间接降低了BDI。它也直接降低了BDI，可能是因为社会交往，积极的强化，和distraction.Conclusion：CHIP，这提高了日常营养的食物和心血管危险因素，也降低了抑郁症。(C)2008年爱思唯尔公司All rights reserved.
Objective: We evaluated the efficacy of the Coronary Health Improvement Project (CHIP) at lowering depression by modifying selected daily nutrients from food.Methods: A randomized controlled trial was used, with 348 participants 24 to 81 y of age from metropolitan Rockford, Illinois. Participants were assessed at baseline and at 6 wk and 6 mo of follow-up. The Beck Depression Inventory (BDI) was used to measure depression.Results: Those in the intervention group compared with the control group were 63% more likely to show a decrease in BDI through 6 wk (P < 0.0001) and 34% more likely to experience a decrease through 6 mo (P < 0.0001). Baseline levels of saturated fat were negatively associated with BDI (P < 0.0001) after adjusting for age, sex, exercise, body mass index, and exercise. Decrease in saturated fat over the study period was directly associated with a decrease in BDI. Increase in pyridoxine (B6) was also associated with a decrease in BDI. The intervention indirectly lowered BDI by lowering saturated fat and increasing dietary pyridoxine (B6). It also directly lowered BDI, possibly because of social interaction, positive reinforcement, and distraction.Conclusion: The CHIP, which improves daily nutrients from food and cardiovascular risk factors, also lowers depression. (C) 2008 Elsevier Inc. All rights reserved.