Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the Amygdala
Memory of social defeat is facilitated by cAMP response element-binding protein overexpression in the Amygdala
复制标题
DOI：
10.1037/0735-7044.119.4.1125
复制
发表时间：
2005-08-01
影响因子：
1.9
通讯作者：
Huhman, KL
中科院分区：
文献类型：
--
作者：
Jasnow, AM;Shi, C;Huhman, KL
CAMP反应元件结合蛋白(CREB)是一种调节突触可塑性和记忆形成的转录因子。使用条件性恐惧模型的研究已经证实，CREB对于获得和巩固恐惧学习很重要。作者证明，暴露在社会失败中的动物的杏仁基底外侧核(BLA)中CREB的过度表达增强了随后失败诱导的社会行为的变化。这一效应是针对失败诱导行为的获得的；如果CREB的过度表达发生在最初的失败之后，则不会对这些行为的表达产生影响。这些数据表明，CREB对调节学习不仅对外显线索很重要，而且对在行为学相关的社会背景下调节行为可塑性也很重要。
The cAMP-responsive element binding protein (CREB) is a transcription factor that regulates synaptic plasticity and memory formation. Studies that have used conditioned fear models have established that CREB is important for the acquisition and consolidation of fear learning. The authors demonstrate that overexpression of CREB within the basolateral amygdala (BLA) of animals that are exposed to social defeat enhances subsequent defeat-induced changes in social behavior. This effect is specific to the acquisition of defeat-induced behaviors; overexpression of CREB has no effect on the expression of these behaviors if the overexpression occurs after the initial defeat. These data demonstrate that CREB is important for regulating learning not only to explicit cues but also for mediating behavioral plasticity in ethologically relevant social contexts.