Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.
Catabolism of fats and branched-chain amino acids in children with Type 1 diabetes: Association with glycaemic control and total daily insulin dose.
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DOI：
10.1002/edm2.448
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发表时间：
2023-11
影响因子：
--
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中科院分区：
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1型糖尿病（T1 D）的高血糖症是由绝对胰岛素缺乏引起的。然而，胰岛素抵抗（IR）可能会加剧T1 D患者的血液不稳定性，并导致长期心血管并发症。我们以前发现，肥胖青少年的IR与支链氨基酸（BCAA）和脂肪酸的性别依赖性紊乱有关。在此，我们假设支链氨基酸和脂肪酸代谢的副产物可以作为青春期前或青春期早期T1 D儿童的血液控制和IR的生物标志物或决定因素。在28名患有T1 D的儿童（15名女性，13名男性;年龄6-11岁）中分析了空腹血液样本中的代谢物，激素和细胞因子。使用主成分分析（PCA）和多元线性回归模型将目标代谢物与血糖控制、每日胰岛素总剂量（TDD，单位/kg/d）、脂联素和甘油三酯（TG）与高密度脂蛋白（HDL）比值相关联。男性和女性在年龄、BMI-z、胰岛素敏感性、血糖控制、炎症标志物、BCAA和C2/C3/C5-酰基肉毒碱方面相当。五氯苯甲醚中保留的大部分成分与脂肪酸氧化（FAO）和支链氨基酸催化剂有关。HbA 1c与因子2（酰基肉毒碱，不完全FAO）和因子9（空腹血糖）呈正相关。TDD与C3、C5和因子10（BCAA催化剂）呈负相关，与C2/C3 + C5比值和因子9（空腹血糖）呈正相关。这些研究结果表明，葡萄糖不耐受在青春期前或青春期早期儿童T1 D伴随着不完全的FAO，而TDD与相对于氨基酸的脂肪的优先catenorism。我们假设支链氨基酸和脂肪酸代谢的副产物可以作为青春期前或青春期早期1型糖尿病（T1 D）儿童血糖控制和胰岛素抵抗（IR）的生物标志物或决定因素。主成分分析和多元线性回归模型被用来相关的代谢物的利益与血糖控制和IR。我们的研究结果表明，葡萄糖不耐受在青春期前或青春期早期儿童T1 D是伴随着不完全的脂肪酸氧化，而每日胰岛素总剂量与优先catenation的脂肪相对于氨基酸。
Hyperglycaemia in Type 1 diabetes (T1D) results from an absolute insulin deficiency. However, insulin resistance (IR) may exacerbate glycaemic instability in T1D and contribute to long‐term cardiovascular complications. We previously showed that IR in teenagers with obesity is associated with sex‐dependent derangements in the catabolism of branched‐chain amino acids (BCAA) and fatty acids. Here we hypothesized that byproducts of BCAA and fatty acid metabolism may serve as biomarkers or determinants of glycaemic control and IR in prepubertal or early pubertal children with T1D. Metabolites, hormones and cytokines from fasting blood samples were analysed in 28 children (15 females, 13 males; age 6–11 years) with T1D. Principal components analysis (PCA) and multiple linear regression models were used to correlate metabolites of interest with glycaemic control, total daily insulin dose (TDD, units/kg/d), adiponectin and the triglyceride (TG) to high‐density lipoprotein (HDL) ratio. Males and females were comparable in age, BMI‐z, insulin sensitivity, glycaemic control, inflammatory markers, BCAAs and C2/C3/C5‐acylcarnitines. The majority of components retained in PCA were related to fatty acid oxidation (FAO) and BCAA catabolism. HbA1c correlated positively with Factor 2 (acylcarnitines, incomplete FAO) and Factor 9 (fasting glucose). TDD correlated negatively with C3 and C5 and Factor 10 (BCAA catabolism) and positively with the ratio of C2 to C3 + C5 and Factor 9 (fasting glucose). These findings suggest that glucose intolerance in prepubertal or early pubertal children with T1D is accompanied by incomplete FAO while TDD is associated with preferential catabolism of fats relative to amino acids. We hypothesized that byproducts of BCAA and fatty acid metabolism may serve as biomarkers or determinants of glycaemic control and insulin resistance (IR) in prepubertal or early pubertal children with Type 1 diabetes (T1D). Principal components analysis and multiple linear regression models were used to correlate metabolites of interest with glycaemic control and IR. Our findings suggest that glucose intolerance in prepubertal or early pubertal children with T1D is accompanied by incomplete fatty acid oxidation while total daily insulin dose is associated with preferential catabolism of fats relative to amino acids.
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影响因子：
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