The biodistribution and pharmacokinetics of meta-iodobenzylguanidine in childhood neuroblastoma

The biodistribution and pharmacokinetics of meta-iodobenzylguanidine in childhood neuroblastoma
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间碘苄胍在儿童神经母细胞瘤中的生物分布和药代动力学

DOI:
10.1007/bf02574771
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发表时间:
2007
期刊:
European Journal of Nuclear Medicine
影响因子:
--
通讯作者:
J. Kemshead
J. Kemshead
中科院分区:
--
文献类型:
--
作者:
L. Lashford;J. Moyes;R. Ott;S. Fielding;J. Babich;S. Mellors;I. Gordon;K. Evans;J. Kemshead

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MIBG在神经母细胞瘤的治疗中引起了相当大的兴趣。本研究调查了神经母细胞瘤儿童在处理化合物时的生物学变化。在接受123 I和131 I-mIBG示踪剂给药的儿童中表征了该化合物的生物分布。已经对肝脏和全身辐射剂量输送进行了估计。结果表明,肝脏剂量输送存在显著的患者间差异。该器官在接受mIBG靶向放疗的某些患者中可能至关重要。
MIBG is generating considerable interest for the treatment of neuroblastoma. This study has investigated the biological variation in handling of the compound in children with neuroblastoma. The biodistribution of the compound has been characterised in children undergoing tracer administrations of123I and131I-mIBG. Estimates of hepatic and whole body radiation dose delivery have been made. The results indicate substantial interpatient variation in hepatic dose delivery. This organ may be critical in some patients undergoing targeted radiotherapy with mIBG.
恶性嗜铬细胞瘤的放射性药物治疗。
DOI: --
发表时间: 1984
期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子: --
作者:
Sisson,JC;Shapiro,B;Beierwaltes,WH;Glowniak,JV;Nakajo,M;Mangner,TJ;Carey,JE;Swanson,DP;Copp,JE;Satterlee,WG
通讯作者: Satterlee,WG
使用 131I-间碘苄基胍通过闪烁扫描法定位嗜铬细胞瘤。
DOI: 10.3322/canjclin.34.2.86
发表时间: 1984
期刊: CA: a cancer journal for clinicians
影响因子: --
作者:
Sisson,JC;Shapiro,B;Beierwaltes,WH;Copp,JE
通讯作者: Copp,JE