Changes in cardiac autonomic regulation after acute lung exposure to carbon nanotubes: implications for occupational exposure
Changes in cardiac autonomic regulation after acute lung exposure to carbon nanotubes: implications for occupational exposure
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DOI：
10.1155/2012/397206
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发表时间：
2012
影响因子：
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通讯作者：
Jacopo M. Legramante;Sergio Sacco;P. Crobeddu;A. Magrini;F. Valentini;G. Palleschi;M. Pallante;R. Balocchi;I. Iavicoli;A. Bergamaschi;A. Galante;L. Campagnolo;A. Pietroiusti
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文献类型：
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作者：
Jacopo M. Legramante;Sergio Sacco;P. Crobeddu;A. Magrini;F. Valentini;G. Palleschi;M. Pallante;R. Balocchi;I. Iavicoli;A. Bergamaschi;A. Galante;L. Campagnolo;A. Pietroiusti
碳纳米管（CNT）是最相关的工程纳米材料（ENM）之一。鉴于预期接触化学物质的人数会增加，有人担心这些物质可能会对接触者的健康产生不利影响。本研究的目的是验证单壁碳纳米管（SWCNTs）肺暴露急性影响清醒大鼠自主心血管调节的假设。我们研究了Wistar-Kyoto大鼠，其中通过手术植入了用于连续动脉压（AP）和心率（HR）记录的遥测发射器。将分散在磷酸盐缓冲盐水（PBS）中或单独的PBS中的SWCNT随机地经皮内施用。在每次滴注前即刻和滴注后24小时，进行30分钟AP记录。采用序列分析法评价压力感受性反射功能。在对照组中，PBS滴注未引起任何显著变化。在方差分析中，SWCNT暴露诱导压力反射系统（BRS）显著降低（3.5 ± 0.6与2.6 ± 0.40 msec/mmHg），而压力反射序列的发生率无显著变化（7.5 ± 0.47%与7.4 ± 0.38%）。我们的研究结果表明，单壁碳纳米管肺暴露可能会影响心血管自主调节，从而有助于心脏和心脏事件。
Carbon nanotubes (CNTs) are among the most relevant engineered nanomaterials (ENMs). Given the expected rise of exposure to ENMs, there is concern that they may adversely affect health of exposed people. Aim of the study was to test the hypothesis that single wall carbon nanotubes (SWCNTs) pulmonary exposure acutely affect the autonomic cardiovascular regulation in conscious rats. We studied Wistar-Kyoto rats in which a telemetry transmitter for continuous arterial pressure (AP) and heart rate (HR) recordings was surgically implanted. SWCNTs dispersed in phosphate buffer saline (PBS) or PBS alone were randomly administered intratracheally. Immediately before, and 24 hours after each instillation a 30 min AP recording was performed. The sequence analysis was performed to evaluate the baroreflex function. In the control group, PBS instillation did not induce any significant changes. At variance the SWCNT exposure induced a significant reduction of baroreflex system (BRS) (3.5 ± 0.6 versus 2.6 ± 0.40 msec/mmHg) without significant changes in the occurrence of baroreflex sequences (7.5 ± 0.47% versus 7.4 ± 0.38%). Our results show that SWCNT pulmonary exposure might affect the cardiovascular autonomic regulation thus contributing to cardiac and arrhythmic events.