Effect of intravenous infusion of a β-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold-pressor stimulation
Effect of intravenous infusion of a β-adrenergic blocking agent on the haemodynamic changes in human masseter muscle induced by cold-pressor stimulation
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DOI：
10.1016/s0003-9969(99)00028-x
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发表时间：
1999-06-01
影响因子：
3
通讯作者：
Clark, GT
中科院分区：
文献类型：
--
作者：
Maekawa, K;Kuboki, T;Clark, GT
8名健康的非吸烟男性（平均年龄：24.1 ± 1.1岁），无任何慢性肌肉疼痛和偏头痛病史，参与了本研究。用无创近红外光谱仪连续记录右咬肌血红蛋白（Hb）和氧（O-2）饱和度。同时记录心率和血压。实验分为三个阶段：安慰剂药物（生理盐水）与冷压试验，30秒最大自主紧握（MVC）试验，和普萘洛尔与冷压试验。生理盐水和药物试验分别包括冷压刺激（4 ℃）前1 min、冷压刺激中2 min和冷压刺激后5 min的连续记录。以2 ml/min的速率输注生理盐水（20 ml）或盐酸普萘洛尔（20 ml）。在基线记录前20 min开始输注，参与者不知道输注的是哪种溶液（生理盐水或普萘洛尔）。在MVC试验中，每个参与者被要求进行30秒的下颌闭合肌肉握紧。每次试验之间有15分钟的休息期。将个体Hb和O-2数据归一化，使得实验开始时的基线等于零，并且将Hb和O-2数据分别归一化为MVC之后和期间个体自身的最高绝对Hb和O-2的百分比。结果显示，β受体阻滞剂试验中冷压刺激前1分钟的平均基线Hb显著低于安慰剂试验（p = 0.035）。在β受体阻滞剂试验中，冷压刺激期间Hb较基线的平均变化也显著小于安慰剂试验（p = 0.035）。在β受体阻滞剂试验中，冷压刺激后的平均Hb反弹变化显著高于安慰剂试验，在冷压刺激后的时间段内未观察到显著的心率差异。总体而言，β受体阻滞剂试验中刺激前和刺激期间的平均心率显著低于安慰剂试验（p < 0.001）。在任何时候，安慰剂和β受体阻滞剂试验之间的平均血压均无显著差异。结果提示，阻断β-肾上腺素能受体可减少静息状态咬肌血容量，抑制冷压刺激时咬肌血容量的增加。并且公开了在该刺激之后的隐藏的血管收缩作用。(C)1999由Elsevier Science Ltd.出版。保留所有权利。
Eight healthy non-smoking males (mean age: 24.1 +/- 1.1 years) without any history of chronic muscle pain and migraine participated in this study. Haemoglobin (Hb) and oxygen (O-2) saturation in the right masseter muscle were continuously recorded with a non-invasive near-infrared spectroscopic device. Heart rate and blood pressure were also recorded. The experiment had three phases: a placebo drug (physiological saline) with cold-presser trial, a 30-sec maximal voluntary clenching (MVC) trial, and a propranolol with cold-presser trial. The saline and drug trials each involved continuous recording for 1 min before, 2 min during and 5 min after the cold-presser stimulation (4 degrees C). Physiological saline (20 ml) or propranolol hydrochloride (20 ml) were infused at the rate of 2 ml/min. This infusion was begun 20 min before the baseline recording and participants did not know which solution (saline or propranolol) was being infused. For the MVC trial, each participant was asked to perform a 30-sec clench of their jaw-closing muscles. There was a rest period of 15 min between each trial. The individual Hb and O-2 data were normalized so that the baseline at the beginning of the experiment was equal to zero, and the Hb and O-2 data were normalized as a percentage of the individual's own highest absolute Hb and O-2 after and during the MVC, respectively. The results showed that the mean baseline Hb 1 min before cold-presser stimulation was significantly lower in the beta-blocker trial than in the placebo trial (p = 0.035). The mean change in Hb from baseline during cold-presser stimulation in the beta-blocker trial was also significantly less than in the placebo trial (p = 0.035). The mean Hb rebound change after the cold-presser stimulation in the beta-blocker trial was significantly higher than in the placebo trial, and no significant heart-rate differences were observed in the period after cold-presser stimulation. Overall, the mean heart rate before and during that stimulation was significantly lower in the beta-blocker trial than the placebo trial (p < 0.001). There was no significant mean blood-pressure difference between placebo and beta-blocker trials at any time. These results suggest that beta-adrenoceptor blocking decreases the blood volume in the resting masseter, suppresses the incremental blood-volume change during cold-presser stimulation. and discloses a hidden vasoconstrictive effect after that stimulation. (C) 1999 Published by Elsevier Science Ltd. All rights reserved.