Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis
Two Unusual Rearranged Flavan Derivatives from Narcissus tazetta var. chinensis
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DOI：
10.1002/hlca.201200248
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发表时间：
2013-02-01
影响因子：
1.8
通讯作者：
Zhang, Wei-Dong
中科院分区：
文献类型：
--
作者：
Fu, Ka-Li;Shen, Yun-Heng;Zhang, Wei-Dong
从中国水仙（Narcissus tazetta var. chinensis Roem）鳞茎中分离到两种具有罕见双环[3.3.1]非3-烯-2,9-二酮环的罕见重排黄酮衍生物tazettone a(1)和tazettone B(2)，以及5种已知黄酮3-7。两个新化合物的结构通过波谱分析，包括一维和二维核磁共振谱进行了阐明。所有分离的化合物对四种人肿瘤细胞系A549、HCT116、SK-BR-3和HepG2的细胞毒性进行了评估。化合物1和2对所有被试细胞系几乎无活性，而化合物3-7对被试细胞系表现出中等或弱的细胞毒性。
Two unusual rearranged flavan derivatives with a rare bicyclo[3.3.1]non-3-ene-2,9-dione ring, tazettone A (1) and tazettone B (2), together with five known flavans, 3-7, were isolated from the bulbs of Narcissus tazetta var. chinensis Roem. The structures of two new compounds were elucidated by spectroscopic analyses, including 1D- and 2D-NMR spectroscopy. All of the isolated compounds were evaluated for their cytotoxicities against four human tumor cell lines A549, HCT116, SK-BR-3, and HepG2. Compounds 1 and 2 were almost inactive against all tested cell lines, while compounds 3-7 exhibited moderate or weak cytotoxicities against the tested cell lines.