COVID-19 in children: what did we learn from the first wave?
COVID-19 in children: what did we learn from the first wave?
复制标题
DOI：
10.1016/j.paed.2020.09.005
复制
发表时间：
2020-12
影响因子：
1.9
通讯作者：
Harwood R
中科院分区：
文献类型：
--
作者：
Bogiatzopoulou A;Mayberry H;Hawcutt DB;Whittaker E;Munro A;Roland D;Simba J;Gale C;Felsenstein S;Abrams E;Jones CB;Lewins I;Rodriguez-Martinez CR;Fernandes RM;Stilwell PA;Swann O;Bhopal S;Sinha I;Harwood R
由新型冠状病毒-严重急性呼吸道综合征-冠状病毒2型（SARS-CoV-2）引起的大流行已造成高死亡率，主要是成人。儿童受SARS-CoV-2的影响要小得多，与成人相比，儿童记录的感染率要低得多，大多数儿童的症状较轻，死亡率也很低。这种疾病的一种疑似晚期表现，即与SARS-CoV-2（PIMS-TS）暂时相关的儿科炎症性多系统综合征，已在少数儿童中观察到，并且比急性SARS-CoV-2具有更严重的病程。这一流行病意味着世界各地的儿童无法上学，与大家庭和朋友隔离，并被要求呆在家里。英国已被宣布处于经济衰退，失业率正在上升。SARS-CoV-2的这些间接影响可能在未来几年对许多儿童产生重大影响。巩固在第一波大流行期间积累的知识，对于认识儿童的临床体征、症状和有效的治疗策略，确定可能面临严重SARS-CoV-2感染风险增加的儿童，规划安全提供对儿童福祉至关重要的保健和非保健相关服务，参与和发展研究，以解决尚不清楚的问题。这篇文章总结了流行病早期出现的证据，并为那些照顾儿童或规划服务的人提供了一个概述。
A pandemic caused by the novel coronavirus, severe acute respiratory syndrome - coronavirus 2 (SARS-CoV-2), has caused high rates of mortality, predominantly in adults. Children are significantly less affected by SARS-CoV-2 with far lower rates of recorded infections in children compared to adults, milder symptoms in the majority of children and very low mortality rates. A suspected late manifestation of the disease, paediatric inflammatory multisystem syndrome - temporally associated with SARS-CoV-2 (PIMS-TS), has been seen in small numbers of children and has a more severe disease course than acute SARS-CoV-2. The pandemic has meant that children around the world have been kept off school, isolated from their extended family and friends and asked to stay inside. The UK has been declared as being in an economic recession and unemployment rates are increasing. These indirect effects of SARS-CoV-2 are likely to have a significant impact on many children for years to come. Consolidating the knowledge that has accumulated during the first wave of this pandemic is essential for recognising the clinical signs, symptoms and effective treatment strategies for children; identifying children who may be at increased risk of severe SARS-CoV-2 infection; planning the safe delivery of healthcare and non-health related services that are important for childrens' wellbeing; and engaging in, and developing, research to address the things that are not yet known. This article summarises the evidence that has emerged from the early phase of the pandemic and offers an overview for those looking after children or planning services.