INFLAMMATORY EDEMA INDUCED BY SYNERGISM BETWEEN CALCITONIN GENE-RELATED PEPTIDE (CGRP) AND MEDIATORS OF INCREASED VASCULAR-PERMEABILITY
INFLAMMATORY EDEMA INDUCED BY SYNERGISM BETWEEN CALCITONIN GENE-RELATED PEPTIDE (CGRP) AND MEDIATORS OF INCREASED VASCULAR-PERMEABILITY
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DOI：
10.1111/j.1476-5381.1985.tb11107.x
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发表时间：
1985-01-01
影响因子：
7.3
通讯作者：
WILLIAMS, TJ
中科院分区：
文献类型：
--
作者：
BRAIN, SD;WILLIAMS, TJ
1.强有力的血管扩张剂降钙素基因相关肽（CGRP，人类合成），当与组胺混合，并在家兔皮内注射，诱导局部水肿的显着增强。2. CGRP还增强由兔中微血管通透性增加的其他介质诱导的水肿;缓激肽、血小板活化因子（Paf）、C5 a des Arg、N-甲酰基-甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）和白三烯B4（LTB 4）。3.单独的P物质或P物质和CGRP的混合物不能诱导兔皮肤水肿。然而，在大鼠皮肤中，P物质引起水肿，这是由CGRP增强。4.家兔皮内注射CGRP后有持久的增强作用。CGRP活性一半丧失的时间为40.1 ± 1.5。7.5与18 .+-相比，前列腺素E2（PGE 2）1分钟。5. CGRP在兔血浆或血液中孵育60分钟后，未检测到增强活性的损失。我们推测，内源性CGRP，如果从神经末梢局部释放，可以有显着的增强作用，对水肿引起的其他介质在炎症反应。
1. The potent vasodilator calcitonin gene-related peptide (CGRP, human synthetic), when mixed with histamine and injected intradermally in the rabbit, induced a marked potentiation of local oedema. 2. CGRP also potentiated oedema induced by other mediators of increased microvascular permeability in the rabbit; bradykinin, platelet-activating factor (Paf), C5a des Arg, N-formyl-methionyl-leucyl-phenylalanine (FMLP) and leukotriene B4 (LTB4). 3. Substance P alone, or mixtures of substance P and CGRP, failed to induce oedema in rabbit skin. In rat skin, however, substance P induced oedema and this was potentiated by CGRP. 4. CGRP had a protracted potentiating action following intradermal injection in the rabbit. The time for half loss of activity for CGRP was 40.1 .+-. 7.5 min compared to 18 .+-. 1 min for prostaglandin E2 (PGE2). 5. No loss of potentiating activity was detected after incubation of CGRP in rabbit plasma or blood for 60 min. 6. We postulate that endogenous CGRP, if released locally from nerve endings, could have a marked enhancing effect on oedema induced by other mediators in an inflammatory reaction.