Resistance to Leishmania major induced by tolerance to a single antigen
Resistance to Leishmania major induced by tolerance to a single antigen
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DOI：
10.1126/science.274.5286.421
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发表时间：
1996-10-18
期刊：
影响因子：
56.9
通讯作者：
Glaichenhaus, N
中科院分区：
文献类型：
--
作者：
Julia, V;Rassoulzadegan, M;Glaichenhaus, N
在小鼠中，对利什曼原虫的易感性与T辅助细胞2（T（H）2）细胞的早期扩增有关，但对这些细胞的特异性一无所知。一个先前确定的抗原，利什曼原虫同源物的受体活化C激酶（LACK），被发现是这个最初的反应的重点。通过胸腺中抗原的转基因表达而对LACK产生耐受的小鼠表现出减少的T（H）2反应和愈合表型。因此，早期激活并对单一抗原有反应的T细胞在指导整个寄生虫的免疫反应中起着关键作用。
In mice, susceptibility to Leishmania major is associated with the early expansion of T helper 2 cells (T(H)2) cells, but nothing is known of the specificity of these cells. A previously identified antigen, Leishmania homolog of receptors for activated C kinase (LACK), was found to be the focus of this initial response. Mice made tolerant to LACK by the transgenic expression of the antigen in the thymus exhibited both a diminished T(H)2 response and a healing phenotype. Thus, T cells that are activated early and are reactive to a single antigen play a pivotal role in directing the immune response to the entire parasite.