Oncogene expression in liver regeneration and hepatocarcinogenesis.
Oncogene expression in liver regeneration and hepatocarcinogenesis.
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肝再生和肝癌发生中的癌基因表达。
DOI：
10.1002/hep.1840030621
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Shank,PR
中科院分区：
文献类型：
--
作者：
Fausto,N;Shank,PR
癌基因的发现和表征已成为癌症研究中最有前途的途径之一，对细胞和病毒癌基因的快速积累的工作已被详尽地回顾（1-4）。在本文中，我们将关注近20种已知癌基因中的5种，即src、ras、mye、abl和mos。首先，我们简要地描述了这些致癌基因的特性，它们与致癌的关系，以及它们在正常发育中的可能作用。然后我们关注这些细胞癌基因在肝脏再生和肝癌发生过程中的表达。虽然还有很多工作要做，我们推测这些观察的可能的生物学意义，并试图为未来的工作指明方向。
The discovery and characterization of oncogenes has become one of the most promising avenues in cancer research and the rapidly accumulating work on cellular and viral oncogenes has been exhaustively reviewed (1-4). In this article, we will be concerned with five of the almost 20 known oncogenes, namely src, ras, mye, abl, and mos. First, we briefly describe the properties of these oncogenes, what is known about their association with carcinogenesis, and their possible role in normal development. We then focus on the expression of these cellular oncogenes during liver regeneration and hepatocarcinogenesis. Although much of the work is still to be done, we speculate on the possible biological significance of these observations and attempt to indicate directions for future work.