Resveratrol, a remarkable inhibitor of ribonucleotide reductase
Resveratrol, a remarkable inhibitor of ribonucleotide reductase
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DOI：
10.1016/s0014-5793(97)01572-x
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发表时间：
1998-01-16
期刊：
影响因子：
3.5
通讯作者：
Guittet, O
中科院分区：
文献类型：
--
作者：
Fontecave, M;Lepoivre, M;Guittet, O
白藜芦醇是葡萄中发现的一种天然植物抗毒素，因其在预防与红葡萄酒消费相关的心脏病中的假定作用而闻名，我们在这里表明，它是哺乳动物细胞中核糖核苷酸还原酶和DNA合成的显着抑制剂，可能进一步应用于人类的抗增殖或癌症化学预防剂。(C)1998年欧洲生物化学学会联合会。
Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption, We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans. (C) 1998 Federation of European Biochemical Societies.