MECHANICAL DEFORMABILITY OF BIOLOGICAL-MEMBRANES AND SPHERING OF ERYTHROCYTE
MECHANICAL DEFORMABILITY OF BIOLOGICAL-MEMBRANES AND SPHERING OF ERYTHROCYTE
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DOI：
10.1016/s0006-3495(73)85981-8
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发表时间：
1973-01-01
影响因子：
3.4
通讯作者：
ADAMS, KH
中科院分区：
文献类型：
--
作者：
ADAMS, KH
机械平衡方程应用于红细胞膜在正常，低张力肿胀和球形构型。如果膜厚度均匀，则所有双凹形状的正常细胞膜上的静水压降均为零。这一结果表明膜张力是均匀的，是膜电位的函数。介绍了一个二维流体膜模型来描述红细胞在低渗溶液中球化过程中不寻常的变形能力。该模型预测了从双凹形状到完美球体的平滑过渡。
Equations of mechanical equilibrium are applied to the erythrocyte membrane in the normal, hypotonically swollen, and sphered configurations. The hydrostatic pressure drop across the normal cell membrane is shown to be zero for all biconcave shapes if the membrane thickness is uniform. This result leads to the conclusion that the membrane tension is uniform and is a function of membrane potential. A two-dimensional fluid film model for the membrane is introduced to describe the unusual deformability of the erythrocyte during sphering in hypotonic solutions. The model predicts a smooth transition from the biconcave shape to a perfect sphere.