[Investigation surrounding a fatal case of yellow fever in Côte d'Ivoire in 1999].
[Investigation surrounding a fatal case of yellow fever in Côte d'Ivoire in 1999].
复制标题
[1999 年科特迪瓦黄热病死亡病例的调查]。
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
A. Ehouman
中科院分区：
文献类型：
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作者：
Akoua;S. Diarrassouba;V. B. Bénié;J. M. Ngbichi;T. Bozoua;A. Bosson;V. Akran;P. Carnevale;A. Ehouman
科特迪瓦是黄热病流行国家，但近年来官方未通报任何病例。然而，1999 年 7 月，报告了一起死亡病例。一名德国公民在该国东北部地区的科莫国家公园被感染。为了评估阿马里尔病毒的传播程度以及对当地民众的风险，卫生部、OCCGE、科特迪瓦巴斯德研究所（IPCI）和世界卫生组织在死亡病例居住地区开展了病毒学、昆虫学和流行病学调查。通过访谈，确定了 18 名疑似捕蚊者和 24 名确诊捕蚊者，并对每人采集了血液样本。此外，还收集了159批蚊子，从中收集了94批潜在媒介；在疑似病例中，22%接种了黄热病疫苗。 IPCI 和巴黎巴斯德研究所通过 ELISA 技术以及对细胞培养物和新生小鼠的分离进行了血清学和病毒学分析。所有可疑血清和87.5%的捕手均呈抗阿马里尔病毒IgG阳性。一名捕手的血清抗阿马里尔病毒 IgM 呈阳性。 11份疑似血清抗登革热病毒IgG呈阳性，其中1份IgM呈阳性。 IPCI 从蚊子中分离出 1 株阿马里尔病毒和 3 株寨卡病毒，并经达喀尔 CRORA 确认。这些结果表明，黄热病和登革热病毒在研究区域的人类和媒介群体中流行。必须采取预防措施来保护有感染阿马里病毒风险的人。
Côte d'Ivoire is an endemic country for yellow fever, but no case was officially notified in recent years. In July 1999, however, one fatal case was reported. A German citizen was infected in the national park of Comoe, in the north eastern area of the country. In order to evaluate the extent of amaril virus circulation and the risk for local people, a virological, entomological and epidemiological investigation was carried out by the ministry of health, the OCCGE, the Côte d'Ivoire Pasteur Institute (IPCI) and the World Health Organisation in the area where the fatal case had been staying. 18 suspected and 24 confirmed mosquito catchers were identified by interview and a blood specimen was collected from each of them. In addition, 159 batches of mosquitoes from which 94 batches of potential vectors were collected; among the suspected cases, 22% were immunised against yellow fever. Serological and virological analyses were made at IPCI and the Paris Pasteur Institute by ELISA technique and isolation on cells cultures and newborn mice. All the suspicious sera and 87.5% of the catchers were positive for IgG anti-amaril virus. One catcher's serum was positive for IgM anti-amaril virus. 11 suspected sera were positive for IgG anti-dengue virus with 1 positive for IgM. 1 strain of amaril virus and 3 strains of Zika virus were isolated from mosquitoes at IPCI and confirmed by CRORA in Dakar. These results indicated that there is a yellow fever and dengue virus are prevalent among the human and vector populations in the study area. Preventive measures must be adopted to protect human beings at risk for amaril infection.