Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain.
Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain.
复制标题
DOI：
10.1016/s1344-6223(02)00133-5
复制
发表时间：
2003-03-01
期刊：
影响因子：
--
通讯作者：
Tsuda, Ryouichi
中科院分区：
文献类型：
--
作者：
Hirose, Wataru;Ikematsu, Kazuya;Tsuda, Ryouichi
血红素氧合酶-1（HO-1）是一种分子量为32 kDa的热休克蛋白（HSP），在脑内催化血红素生成胆绿素、游离铁和一氧化碳。此外，HO-1释放游离亚铁离子在铁蛋白合成中起重要作用，铁蛋白储存铁用于细胞内利用或解毒。众所周知，在各种病理生理条件下，海马和大脑皮层的神经元和胶质细胞中HO-1免疫反应性大大增强。HSP 70的表达与年龄相关，但HO-1和铁蛋白的表达模式与衰老相关仍不清楚。因此，进行了一项研究，以检查HO-1和铁蛋白的表达与年龄的相关性，使用免疫组织化学。我们研究了31例尸检的大脑（3-84岁），没有创伤性脑损伤和神经退行性疾病。标本取自大脑皮层和海马。在大脑皮层，年龄（增龄）与HO-1呈显著正相关（r=0.894，P
Heme oxygenase-1 (HO-1) is a 32 kDa heat shock protein (HSP) that catalyzes heme to biliverdin, free iron and carbon monoxide in the brain. Furthermore, the release of free ferrous ion by HO-1 plays an essential role in ferritin synthesis, and ferritin stores iron either for intracellular utilization, or for detoxification. It is well known that HO-1 immunoreactivity is enhanced greatly in neurons and glia of the hippocampus and cerebral cortex in various pathophysiological conditions. The expression of HSP 70 is well known for the age-associated increase, but the expression modalities of HO-1 and ferritin associated with aging are still unknown. A study was therefore performed to examine the correlations in the expression of HO-1 and ferritin with age using immunohistochemistry. We investigated 31 autopsied brains (3-84-year-olds) without traumatic brain injury and neurodegenerative disease. The specimens were taken from the cerebral cortex and hippocampus. In the cerebral cortex, age (aging) had a statistically significant positive correlation with HO-1 (r=0.894, P