NON-INVASIVE DIAGNOSIS OF NEONATAL ASPHYXIA AND INTRA-VENTRICULAR HEMORRHAGE BY DOPPLER ULTRASOUND
NON-INVASIVE DIAGNOSIS OF NEONATAL ASPHYXIA AND INTRA-VENTRICULAR HEMORRHAGE BY DOPPLER ULTRASOUND
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DOI：
10.1016/s0022-3476(79)80735-0
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发表时间：
1979-01-01
影响因子：
5.1
通讯作者：
SUMNER, DS
中科院分区：
文献类型：
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作者：
BADA, HS;HAJJAR, W;SUMNER, DS
应用多普勒超声监测脑前动脉搏动性血流变化，观察窒息和脑室内出血时脑血管血流动力学的变化。测定4组新生儿的搏动指数[PI]，其中I组为正常足月组21例，II组为窒息组12例，III组为ICIVH组14例，IV组为无症状早产儿11例。与正常足月儿相比，诊断为窒息的早产儿PI值显著降低，而IC-IVH组的PI值显著高于无症状早产儿。对22例有呼吸窘迫的早产儿进行了连续的多普勒检查。在这些婴儿中，有一半后来发展为IC-IVH。在出血前，他们的PI测量值明显低于那些最终没有并发症的人。窒息和IC-IVH发作前的低PI值表明血管扩张和血流阻力降低。在IC-IVH中，高PI测量表示相反的情况。在呼吸窘迫的婴儿中，当存在显著的血管扩张和血管阻力降低时，脑血流量可能会增加到过高的水平，导致IC-IVH。
The cerebrovascular hemodynamic alterations in asphyxia and intracerebral-intraventricular hemorrhage [IC-IVH] were determined by monitoring the pulsatile flow changes in the anterior cerebral arteries using Doppler ultrasound. The pulsatility index [PI] measurements, which were calculated from the recorded changes in Doppler frequency shifts, were obtained in 4 groups of newborn infants: group I-normal term (n = 21); group II-asphyxia (n = 12); group III-IC-IVH (n = 14); and group IV-asymptomatic preterm (n = 11). There was no significant difference between PI values of groups I and IV. Compared to normal term infants, those diagnosed as having asphyxia had significantly lower PI measurements and those with IC-IVH had significantly higher PI values than the asymptomatic preterm infants. Serial Doppler studies were also performed in 22 preterm infants with respiratory distress. Of these infants, half subsequently developed IC-IVH. Prior to hemorrhage, their PI measurements were significantly lower than those who did not eventually have the complication. The low PI values in asphyxia and prior to the onset of IC-IVH indicate vasodilation and decreased resistance to blood flow. In IC-IVH, the high PI measurements denote the opposite. In infants with respiratory distress in the presence of significant vasodilation and lowered vascular resistance, cerebral blood flow may increase to excessive levels, resulting in IC-IVH.