Stage dependent variation in Mn2+-sensitive adenylyl cyclase (AC) activity in spermatids and FSH-sensitive AC in sertoli cells.
Stage dependent variation in Mn2+-sensitive adenylyl cyclase (AC) activity in spermatids and FSH-sensitive AC in sertoli cells.
复制标题
精子细胞中 Mn2 敏感腺苷酸环化酶 (AC) 活性和支持细胞中 FSH 敏感 AC 活性的阶段依赖性变化。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
V. Hansson
中科院分区：
文献类型：
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作者：
J. Gordeladze;M. Parvinen;O. Clausen;V. Hansson
本文研究了生精上皮周期不同阶段(I-XIV)精子细胞中特异性Mn2+依赖的腺苷环化酶(AC)活性和支持细胞对卵泡刺激素(FSH)反应的AC活性的变化。依赖Mn2+的AC活性在II-III期达到最大值，而在VII-VIII期(受精)最低。FSH反应的AC活性表现出与依赖Mn2+的AC一致的模式。精子细胞AC活性的阶段依赖性变化不能用单倍体细胞数量的变化来解释。这就提出了一个问题，即支持细胞是否可能调节精子细胞的AC活性。处于不同阶段的支持细胞都暴露在相同浓度的循环激素中。因此，FSH反应性的阶段依赖性差异表明局部影响(来自生殖细胞？)可能参与调节支持细胞AC对FSH的反应。
The variation of the specific Mn2+-dependent adenylyl cyclase (AC activity in spermatids and follicle stimulating hormone (FSH)-responsive AC activities in Sertoli cells in different stages (I-XIV) of the seminiferous epithelial cycle has been investigated. Maximal Mn2+-dependent AC activity was observed in stages II-III while minimal activity was encountered in stages VII-VIII (spermiation). FSH-responsive AC activity exhibited a pattern that coincided with that of the Mn2+-dependent AC. The stage-dependent variation in spermatid AC activity cannot be explained by altered numbers of haploid cells. This raises the question whether the Sertoli cells may regulate the spermatid AC activity. Sertoli cells in various stages are all exposed to the same concentration of circulatory hormones. Hence the stage-dependent difference in FSH-responsiveness indicates that local influences (from germ cells?) may regulate the response of the AC in Sertoli cells to FSH.