V2R gene families degenerated in primates, dog and cow, but expanded in opossum.
V2R gene families degenerated in primates, dog and cow, but expanded in opossum.
复制标题
DOI：
10.1016/j.tig.2007.03.004
复制
发表时间：
2007-05
期刊：
影响因子：
--
通讯作者：
Janet M. Young;B. Trask
中科院分区：
文献类型：
--
作者：
Janet M. Young;B. Trask
The V2R genes are expressed in the mammalian vomeronasal organ, and their products are involved in detecting pheromones. Here, we describe the evolution of the V2R gene family. We have found that the human, chimpanzee, macaque, cow and dog V2R gene families have completely degenerated. Each now contains 9–20 pseudogenes but no intact V2R genes. By contrast, opossum has ∼90 intact V2R genes that mostly arose by duplication after opossum and rodent lineages diverged. One V2R gene subfamily with unusual biology evolved atypically, showing limited expansion in rodents and persistence of a single, albeit sometimes dysfunctional, ortholog in all other species examined.
