Outcome of influenza infection: effect of site of initial infection and heterotypic immunity.
Outcome of influenza infection: effect of site of initial infection and heterotypic immunity.
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流感感染的结果：初始感染部位和异型免疫的影响。
DOI：
10.1128/iai.29.2.654-662.1980
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发表时间：
1980
影响因子：
3.1
通讯作者：
SmallJr,PA
中科院分区：
文献类型：
--
作者：
Yetter,RA;Lehrer,S;Ramphal,R;SmallJr,PA
在小鼠的整个呼吸道中建立的高度肺适应性流感病毒（H 0 N1）感染导致病毒性肺炎死亡。50%致死剂量（LD 50）与50%感染剂量（ID 50）大致相同。在鼻粘膜中开始的相同病毒的感染在3至5天内扩散到气管和肺，但除非在非常高的感染剂量下，否则不会致命。LD 50是ID 50的30，000倍。从A/PC/73（H3 N2）先前感染中恢复的小鼠在用A/PR/8/34（H 0 N1）攻击时表现出增强的恢复（异型免疫）。在用这种潜在致命病毒麻醉的情况下感染的异型免疫小鼠在第7天停止从鼻子、气管和肺部排出病毒并恢复。异源免疫小鼠在清醒状态下感染，到第5天停止从鼻子中排出病毒，事实上，病毒没有传播到气管或肺部。因此，流感感染严重程度的一些变化可以用两个因素来解释：初始感染的部位和以前感染过异型流感病毒。
An infection established throughout the total respiratory tract of mice with a highly lung adapted influenza virus (H0N1) led to death from viral pneumonia. The 50% lethal dose (LD50) was approximately the same as the 50% infectious dose (ID50). An infection with the same virus initiated in the nasal mucosa spread to the trachea and lungs over a 3- to 5-day period but was not lethal except at very high infecting doses. The LD50was 30,000 times the ID50. Mice that had recovered from a prior infection with A/PC/73(H3N2) demonstrated enhanced recovery (heterotypic immunity) when challenged with A/PR/8/34(H0N1). Heterotypically immune mice infected while anesthetized with this potentially lethal virus stopped shedding virus from the nose, trachea, and lungs by day 7 and recovered. Heterotypically immune mice, infected awake, stopped shedding virus from the nose by day 5, and, in fact, the virus did not spread to the trachea or lungs. Thus, some of the variation in the severity of influenza infections may be explained by two factors: the site of initial infection and previous infection with heterotypic influenza virus.