Herpes zoster ophthalmicus and the risk of stroke
Herpes zoster ophthalmicus and the risk of stroke
复制标题
眼部带状疱疹与中风的风险
作者：
Herng‐Ching Lin;Ching;J. Ho
目的：探讨眼带状疱疹（HZO）患者发生脑卒中的危险性。方法：资料来源于台湾全民健康保险研究资料库。研究队列包括2003年和2004年诊断为HZO（ICD-9-CM代码053.2）的所有患者（n = 658）。比较队列由随机选择的患者（每例HZO患者3例，n = 1974）组成，这些患者在年龄和性别方面与研究组匹配。患者从索引访视开始跟踪1年。采用Kaplan-Meier法计算1年无卒中生存率。进行考克斯比例风险回归，计算校正可能的混杂因素后的1年无卒中生存率。结果：在1年随访期间，HZO患者中有8.1%发生卒中，对照队列中有1.7%发生卒中。HZO患者的1年无卒中生存率显著低于对照组。在调整患者的人口统计学特征、选定的合并症和用药习惯后，发现HZO患者的卒中风险比匹配的对照队列高4.52倍（95%置信区间2.45-8.33）。接受过全身抗病毒治疗的患者和未接受过全身抗病毒治疗的患者之间的卒中发生率没有显著差异。结论：带状疱疹眼可能是一个标志物的风险增加中风的发展在1年的随访期间。
Objective: To investigate the risk of stroke development following a diagnosis of herpes zoster ophthalmicus (HZO). Methods: Data were retrospectively collected from the Taiwan National Health Insurance Research Database. The study cohort comprised all patients with a diagnosis of HZO (ICD-9-CM code 053.2) in 2003 and 2004 (n = 658). The comparison cohort was comprised of randomly selected patients (3 for every HZO patient, n = 1974) matched with the study group in terms of age and gender. Patients were tracked from their index visits for 1 year. The Kaplan-Meier method was utilized to compute the 1-year stroke-free survival rate. Cox proportional hazard regressions were carried out to compute the adjusted 1-year stroke-free survival rate after adjusting for possible confounding factors. Results: Stroke developed in 8.1% of patients with HZO and 1.7% of patients in the comparison cohort during the 1-year follow-up period. HZO patients had significantly lower 1-year stroke-free survival rates than patients in the comparison cohort. After adjusting for patients' demographic characteristics, selected comorbidities, and medication habits, HZO patients were found to have a 4.52-fold (95% confidence interval 2.45–8.33) higher risk of stroke than the matched comparison cohort. There was no significant difference in the rate of stroke development between patients who had received systemic antiviral treatment and those who had not. Conclusions: Herpes zoster ophthalmicus may represent a marker of increased risk of stroke development during the 1-year follow-up period.
影响因子：
2.4
作者：
Mueller, Niklaus H.;Gilden, Donald H.;Cohrs, Randall J.;Mahalingam, Ravi;Nagel, Maria A.
通讯作者：
Nagel, Maria A.