Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis
Reduced Levels of Serum Pigment Epithelium-Derived Factor in Women With Endometriosis
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子宫内膜异位症女性血清色素上皮衍生因子水平降低
DOI：
10.1177/1933719111413300
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发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Zhang, Xinmei
中科院分区：
文献类型：
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作者：
Chen, Liqing;Fan, Ruijia;Zhang, Xinmei
作者先前证实，与非子宫内膜异位症女性相比，子宫内膜异位症女性腹腔液中色素上皮衍生因子（PEDF）水平降低。在这里，作者确定子宫内膜异位症妇女血清中PEDF水平是否改变。在腹腔镜手术前采集了71例子宫内膜异位症患者和非子宫内膜异位症患者（分别为43例和28例）的外周血样本。酶联免疫吸附法测定血清PEDF浓度。我们检测到子宫内膜异位症患者血清PEDF水平（16.3 ± 6.6 ng/mL）低于非子宫内膜异位症患者（24.5 ± 7.3 ng/mL; P <0.001）。在子宫内膜异位症患者中，疼痛患者的血清PEDF浓度（n = 11，12.6 ± 7.1 ng/mL）显著低于无疼痛患者（n = 32，17.5 ± 6.0 ng/mL; P <0.05）。血清PEDF浓度与疾病分期、部位及不孕无关。此外，血清PEDF浓度在两组的周期阶段中均未显示出任何差异。我们的研究结果表明，子宫内膜异位症和疾病相关疼痛的妇女血清PEDF水平降低可能在这种疾病的发病机制中发挥作用。
The authors previously demonstrated decreased levels of pigment epithelium-derived factor (PEDF) in peritoneal fluid of women with endometriosis compared to women without endometriosis. Here, the authors determine whether women with endometriosis have altered levels of PEDF in serum. Peripheral blood samples were collected from 71 women with and without endometriosis (n = 43 and 28, respectively) before laparoscopic surgery. Concentrations of serum PEDF were measured by enzyme-linked immunosorbent assay. We detected lower levels of serum PEDF in women with endometriosis (16.3 ± 6.6 ng/mL) than in those without endometriosis (24.5 ± 7.3 ng/mL; P < .001). In women with endometriosis, the concentrations of serum PEDF were significantly lower in women with pain (n = 11, 12.6 ± 7.1 ng/mL) compared to women without pain (n = 32, 17.5 ± 6.0 ng/mL; P < .05). However, the concentrations of serum PEDF did not correlate with disease stage or site or infertility. In addition, the concentrations of serum PEDF did not show any difference in the phase of the cycle in either group. Our results suggest that reduced levels of serum PEDF in women with endometriosis and disease-related pain may play a role in the pathogenesis of this disease.