Sphingosine kinase 1 in cancer.
Sphingosine kinase 1 in cancer.
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DOI：
10.1016/b978-0-12-394274-6.00007-8
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发表时间：
2013
影响因子：
--
通讯作者：
Obeid LM
中科院分区：
文献类型：
--
作者：
Heffernan-Stroud LA;Obeid LM
鞘磷脂作为生物活性信号分子可以调节细胞命运决定，这使它们处于癌症治疗和预防的中心阶段。神经酰胺和鞘氨醇已被确定为抑制生长的分子，而鞘氨醇-1-磷酸(S1P)向细胞提供促进生长的信息。负责维持这些“停止”或“继续”信号之间的平衡的酶是鞘氨醇激酶(SK)、SK1和SK2。虽然SK2的相对作用仍在阐明中，并可能涉及核内的作用，但大量证据表明，SK1对鞘脂水平的调节是致癌的重要组成部分。在这里，我们回顾了关于SK1作为癌基因的作用的文献，它可以提高癌细胞的活力和促进肿瘤的生长和转移；强调了开发特定的SK1抑制剂来补充当前癌症治疗的重要性。
The role of sphingolipids as bioactive signaling molecules that can regulate cell fate decisions puts them at center stage for cancer treatment and prevention. While ceramide and sphingosine have been established as antigrowth molecules, sphingosine-1-phosphate (S1P) offers a progrowth message to cells. The enzymes responsible for maintaining the balance between these “stop” or “go” signals are the sphingosine kinases (SK), SK1 and SK2. While the relative contribution of SK2 is still being elucidated and may involve an intranuclear role, a substantial amount of evidence suggests that regulation of sphingolipid levels by SK1 is an important component of carcinogenesis. Here, we review the literature regarding the role of SK1 as an oncogene that can function to enhance cancer cell viability and promote tumor growth and metastasis; highlighting the importance of developing specific SK1 inhibitors to supplement current cancer therapies.