E-cadherin as a prognostic marker in human serous carcinomas of the ovary: an immunohistochemical analysis
E-cadherin as a prognostic marker in human serous carcinomas of the ovary: an immunohistochemical analysis
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DOI：
10.1007/s00404-010-1657-0
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发表时间：
2011-08-01
影响因子：
2.6
通讯作者：
Mylonas, Ioannis
中科院分区：
文献类型：
--
作者：
Dian, Darius;Bruening, Ansgar;Mylonas, Ioannis
卵巢癌是一种死亡率很高的妇科癌症，在分期和治疗过程中需要有效可靠的肿瘤标志物。用免疫组织化学方法分析了100例卵巢癌组织样本中E-cadherin的表达。E-cadherin表达与组织学分级（p = 0.001）和手术分期（p = 0.020）有显著相关性。然而，E-cadherin的染色强度与浆液性卵巢癌的无进展、病因特异性生存期或总生存期无显著相关性。E-cadherin表达与严重卵巢癌的FIGO手术分期和组织学分化相关，提示其在浆液性卵巢癌的癌变过程中起重要作用。然而，虽然E-cadherin染色强度高的患者预后较好，但没有统计学上的显著差异。因此，e -钙粘蛋白可能不是浆液性卵巢癌的有效预后肿瘤标志物。
Ovarian cancer is a gynecologic cancer with a high mortality rate, demonstrating the need for effective and reliable tumor markers during the staging and treatment processes.Expression of E-cadherin was immunohistochemically analyzed in 100 ovarian cancer tissue samples.A significant association of E-cadherin expression with histological grading (p = 0.001) and surgical stage (p = 0.020) could be demonstrated. However, the staining intensity of E-cadherin was not significantly associated with progression-free, cause-specific survival or overall survival in serous ovarian carcinomas.The E-cadherin expression was associated with FIGO surgical staging and histological differentiation in serious ovarian carcinomas, suggesting a substantial role in the carcinogenesis of serous ovarian carcinomas. However, although patients with a strong E-cadherin staining intensity had a better prognosis, no statistical significant differences could be observed. Therefore, E-cadherin might not be a useful prognostic tumor marker in serous ovarian carcinomas.