Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds
Immunomodulatory and antimetastatic action of propolis and related polyphenolic compounds
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DOI：
10.1016/j.jep.2004.06.006
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发表时间：
2004-10-01
影响因子：
5.4
通讯作者：
Basic, I
中科院分区：
文献类型：
--
作者：
Orsolic, N;Knezevic, AH;Basic, I
本文研究了枸杞多酚类化合物对CBA小鼠可移植性乳腺癌生长和转移的影响。通过静脉注射肿瘤细胞（2 × 10（5））产生肺转移。将蜂胶水溶性衍生物（WSDP）、咖啡酸（CA）、咖啡酸苯乙酯（CAPE）和槲皮素（QU）在接种肿瘤细胞前经口给予小鼠。测试的化合物显著减少了肺中肿瘤结节的数量。根据所获得的结果，测试化合物的抗肿瘤活性可以与化合物的免疫调节性质、它们对肿瘤细胞的细胞毒性以及它们诱导细胞凋亡和坏死的能力相关。实验数据支持WSDP、CA、CAPE和QU在控制实验模型中的肿瘤生长方面可能是潜在有用的。(C)2004爱思唯尔爱尔兰有限公司保留所有权利。
The effect of polyphenolic compounds isolated from propolis and propolis itself was investigated on the growth and metastatic potential of a transplantable mammary carcinoma (MCa) of CBA mouse. Metastases in the lung were generated by intravenous injection Of tumor cells (2 x 10(5)). A water-soluble derivative of proplis (WSDP), caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and quercetin (QU) were given to mice, per os before tumor cells inoculation. Tested compounds significantly decreased the number of tumor nodules in the lung. According to the results obtained the antitumor activity of tested compounds can be related to the immunomodulatory properties of the compounds, their cytotoxicity to tumor cells, and their capacity to induce apoptosis and necrosis. The experimental data support that WSDP, CA, CAPE and QU could be potentially useful in the control of tumor growth in experimental models. (C) 2004 Elsevier Ireland Ltd. All rights reserved.