Optimization of Contact Lenses for Corneal Protection During Vitreoretinal Surgery.
Optimization of Contact Lenses for Corneal Protection During Vitreoretinal Surgery.
复制标题
玻璃体视网膜手术期间角膜保护隐形眼镜的优化。
DOI：
10.1097/icl.0000000000000764
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Liu Qinghuai
中科院分区：
文献类型：
--
作者：
Sang Shan;Miao Jinxin;Hu Zizhong;Yuan Songtao;Xie Ping;Liu Qinghuai
目的：优化角膜接触镜（CL）的参数，评价CL在玻璃体视网膜手术中对角膜的保护作用。方法：在模拟玻璃体视网膜手术的条件下，比较平衡盐溶液、粘弹剂和CL对兔角膜的保护作用。我们评估了不同厚度的CL，并比较了聚甲基丙烯酸甲酯（PMMA）和透气性氟硅丙烯酸酯（XO）镜片对兔角膜和严重增生性糖尿病视网膜病变（PDR）患者角膜的保护作用。结果：PMMA组的角膜荧光素染色评分（FSS）明显低于平衡盐水组和粘弹剂组。PMMA透镜的厚度对FSS没有显著影响。PMMA组的FSS显著高于XO组。在PDR患者中，玻璃体视网膜手术后第1天，PMMA组的FSS显著高于XO组，但术后第7天无显著差异。结论：无论XO透镜的厚度如何，在非接触性玻璃体视网膜手术中，XO透镜能更好地保护角膜，在玻璃体切除术中，能更有效地保护角膜上皮。
Objectives:To optimize parameters of contact lenses (CLs) and evaluate their ability to protect the cornea during vitreoretinal surgery.Methods:We compared the protective effects of balanced saline solution, viscoelastic agent, and CLs on rabbit corneas under conditions simulating vitreoretinal surgery. We evaluated CLs of different thicknesses and compared the protective effects of polymethyl methacrylate (PMMA) and gas-permeable fluorosilicone acrylate (XO) lenses on the corneas of rabbits and patients with severe proliferative diabetic retinopathy (PDR). The corneal fluorescein staining score (FSS) was measured to compare the protective effects of CLs.Results:The FSS was significantly lower in the PMMA group than in the balanced saline solution and viscoelastic agent groups. The thickness of the PMMA lenses had no significant effect on the FSS. The FSS was significantly higher in the PMMA group than in the XO group. In patients with PDR, on day 1 after vitreoretinal surgery, the FSS was significantly higher in the PMMA group than in the XO group, although no significant difference was observed on postoperative day 7.Conclusion:The XO lens offers better corneal protection during noncontact wide-angle vitreoretinal surgery and protects the corneal epithelium more efficiently during vitrectomy in patients with PDR, irrespective of its thickness.