HEART-RATE AND ARTERIAL BLOOD-PRESSURE AT THE ONSET OF STATIC EXERCISE IN MAN WITH COMPLETE NEURAL BLOCKADE
HEART-RATE AND ARTERIAL BLOOD-PRESSURE AT THE ONSET OF STATIC EXERCISE IN MAN WITH COMPLETE NEURAL BLOCKADE
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DOI：
10.1113/jphysiol.1990.sp018038
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发表时间：
1990-04-01
影响因子：
5.5
通讯作者：
SECHER, NH
中科院分区：
文献类型：
--
作者：
FRIEDMAN, DB;JENSEN, FB;SECHER, NH
1. 我们通过完全阻断工作肌肉的传入神经，测试了“肌肉-心脏反射”假说，即在人体静态运动开始时心率和血压立即增加。在用利多卡因联合腋窝和桡骨阻断前后，进行短暂（5 s）的最大静态手握收缩，没有进行Valsalva-like操作，中心静脉压没有增加。肌肉力量几乎降至零。传入神经阻断的有效性是通过记录心率和血压反应，以及对被阻断的手和对侧未被阻断的手进行冷压试验时的感知疼痛评分来评估的。2. 冷压试验使血压升高，但对心率没有影响。传入神经阻断消除了与冷压试验相关的血压升高和感知疼痛。在手臂传入神经阻滞前后，最大的握力收缩导致心率和血压立即和类似的增加。3. 这项研究的结果表明，在静态运动开始时，心率和血压的立即增加发生在“肌肉-心脏反射”无法操作的情况下。
1. We tested the ''muscle-heart reflex'' hypothesis for the immediate increases in heart rate and blood pressure at the onset of static exercise in man by performing complete blockade of afferent nerves from the working muscles. Brief (5 s) maximal static hand-grip contractions were performed without performing a Valsalva-like manoeuvre and with no increase in central venous pressure both before and after combined axillary and radial blockade with lidocaine. Muscle strength was reduced to near zero. The effectiveness of the afferent neural blockade was evaluated by recording the heart rate and blood pressure responses and rating the perceived pain during a cold pressor test of the blocked and contralateral unblocked hand. 2. The cold pressor test increased blood pressure but had no effect on heart rate. Afferent neural blockade eliminated the increase in blood pressure and the perceived pain associated with the cold pressor test. Maximal hand-grip contractions resulted in immediate and similar increases in heart rate and blood pressure before and after afferent neural blockade of the arm. 3. The results of this study suggest that the immediate increases in heart rate and blood pressure at the onset of static exercise in man occur when the ''muscle-heart reflex'' is inoperable.