Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
Cytoskeletal proteins talin and vinculin in integrin-mediated adhesion
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DOI：
10.1042/bst0320831
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发表时间：
2004-11-01
影响因子：
3.9
通讯作者：
Critchley, DR
中科院分区：
文献类型：
--
作者：
Critchley, DR
细胞骨架蛋白talin和vinculin在整合素介导的细胞与细胞外基质连接的细胞质面上形成大分子复合物的一部分。最近的遗传、生化和结构数据表明，talin 对于此类连接的组装至关重要，而纽蛋白似乎在调节粘附动力学和细胞迁移方面很重要。
The cytoskeletal proteins talin and vinculin form part of a macromolecular complex on the cytoplasmic face of integrin-mediated cellular junctions with the extracellular matrix. Recent genetic, biochemical and structural data show that talin is essential for the assembly of such junctions, whereas vinculin appears to be important in regulating adhesion dynamics and cell migration.